Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer

Increased expression of cancer-associated fibroblast markers at the invasive front and its association with tumor-stroma ratio in colorectal cancer

Abstract Background The tumor microenvironment has a critical role in regulating cancer cell behavior. Tumors with high stromal content are associated with poor patient outcome. The tumor-stroma ratio (TSR) identifies colorectal cancers (CRC) with poor patient prognosis based on hematoxylin & eo...

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Bibliographic Details
Main Authors: Tessa P. Sandberg, Maaike P. M. E. Stuart, Jan Oosting, Rob A. E. M. Tollenaar, Cornelis F. M. Sier, Wilma E. Mesker
Format: Article
Language:English
Published: BMC 2019-03-01
Series:BMC Cancer
Subjects:
Cancer-associated fibroblasts
Tumor microenvironment
Tumor-stroma ratio
FAP
Colorectal cancer
Online Access:http://link.springer.com/article/10.1186/s12885-019-5462-2

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