Divergent Mitochondrial Antioxidant Activities and Lung Alveolar Architecture in the Lungs of Rats and Mice at High Altitude

Divergent Mitochondrial Antioxidant Activities and Lung Alveolar Architecture in the Lungs of Rats and Mice at High Altitude

Compared with mice, adult rats living at 3,600 m above sea level (SL—La Paz, Bolivia) have high hematocrit, signs of pulmonary hypertension, and low lung volume with reduced alveolar surface area. This phenotype is associated with chronic mountain sickness in humans living at high altitude (HA). We...

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Bibliographic Details
Main Authors: Alexandra Jochmans-Lemoine, Susana Revollo, Gabriella Villalpando, Ibana Valverde, Marcelino Gonzales, Sofien Laouafa, Jorge Soliz, Vincent Joseph
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Physiology
Subjects:
oxidative stress
mitochondria
high altitude
lung
postnatal hypoxia
Online Access:http://journal.frontiersin.org/article/10.3389/fphys.2018.00311/full

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