Effect of Artemisia herb on induced hyperglycemia in wistar rats

• Main Authors: Zainab Abul-khalik Ahmad, Bahaa Amin Abdul-Hussian
• Format: Article
• Language: English
• Published: College of Veterinary Medicine 2016-12-01
• Series: Al-Qadisiyah Journal of Veterinary Medicine Sciences
• Online Access: http://www.qu.edu.iq/journalvm/index.php/vm_journal/article/view/398

The study was carried out to evaluate the hypoglycemic effect of Artemisia herb aqueous extract on postprandial blood glucose in normoglycemic and dexamethasone-induced hyperglycemic Wistar rats. Sixty adult male Wistar rats were used; rats were assigned to six equal groups (10 per each). Hyperglycemia had been induced in 40 rats by injection of a single dose of dexamethasone (8 mg/2 ml, s.c.). Normal groups drenched the herb extract orally and with drinking water in 100%, and 50% concentration (NA100%, NA50%) respectively. After induction and ensuring of hyperglycemia, distil water (DW), and the (PIA100%, PIA50%) treated groups with herb extract 100%, 50% concentration respectively, finally the (M) group (metformin 500mg/ml) was treated by drenched with metformin 500 mg orally for 10 consecutive days for all group. Results were revealed that drenching of Artemisia herba- alba herb 100% aqueous extract has a highly significant (p<0.01) hypoglycemic effect on postprandial blood glucose in both normoglycemic and hyperglycemic rats comparing to normal values and to metformin respectively, whereas hypoglycaemic effect of Ah extract 50% was significant (p<0.05) on postprandial blood glucose in normoglycemic rats comparing to normal values and highly significant (p<0.01) in hyperglycemic rats comparing to metformin. It can be concluded that drenching of aqueous extract of Ah has potent hypoglycemic effect in experimentally induced hyperglycemic rats.