TLR9 ligand induces the generation of CD20+ plasmablasts and plasma cells from CD27+ memory B-cells

TLR9 ligand induces the generation of CD20+ plasmablasts and plasma cells from CD27+ memory B-cells

Plasma cells have a heterogeneous phenotype in humans. While bone marrow plasma cells are CD20-CD138+, tonsil plasma cells are CD20+CD138+/- and peripheral plasmablasts are CD20-CD138-. In vitro, plasma cells are mainly generated by the activation of CD27+ memory B-cells through transient stimulatio...

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Bibliographic Details
Main Authors: Alexandrine eGeffroy-Luseau, David eChiron, Géraldine eDescamps, Gaëtan eJégo, Martine eAmiot, Catherine ePellat-Deceunynck
Format: Article
Language:English
Published: Frontiers Media S.A. 2011-12-01
Series:Frontiers in Immunology
Subjects:
Plasma Cells
Survival
human
CpG
CD20
CD27+
Online Access:http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00083/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fimmu.2011.00083/full

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