Gene Families With Stochastic Exclusive Gene Choice Underlie Cell Adhesion in Mammalian Cells

Gene Families With Stochastic Exclusive Gene Choice Underlie Cell Adhesion in Mammalian Cells

Exclusive stochastic gene choice combines precision with diversity. This regulation enables most T-cells to express exactly one T-cell receptor isoform chosen from a large repertoire, and to react precisely against diverse antigens. Some cells express two receptor isoforms, revealing the stochastic...

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Bibliographic Details
Main Authors: Mikhail Iakovlev, Simone Faravelli, Attila Becskei
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
allelic exclusion
carbonic anhydrase
cell identity
Poisson-binomial distribution
single-cell RNA-seq
basigin
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2021.642212/full

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