Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins
Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L-tyrosine, the substrate for tyrosinase. In this repor...
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| Format: | Article |
| Language: | English |
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De Gruyter
1995-08-01
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| Series: | Pteridines |
| Online Access: | https://doi.org/10.1515/pteridines.1995.6.3.101 |
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doaj-23c53ee07adc421c8ac8964d176ec119 |
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Article |
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doaj-23c53ee07adc421c8ac8964d176ec1192021-09-05T13:59:59ZengDe GruyterPteridines0933-48072195-47201995-08-016310110310.1515/pteridines.1995.6.3.101Control of Melanogenesis In the Human Epidermis by the Redox-Status of TetrahydrobiopterinsSchallreuter-Wood Karin U.0Wood John M.1Department of Biomedical Sciences, University of Bradford, U.K.Department of Biomedical Sciences, University of Bradford, U.K.Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L-tyrosine, the substrate for tyrosinase. In this report, we present evidence that 6-BH4 and other tetrahydropterins, have the capacity to regulate tyrosinase activity directly by a specific uncompetitive mechanism. This fine control of tyrosinase activity/melanogenesis in the human epiidermis depends on the redox equilibrium 6-BH4 ↔ dihydropterin ↔ 6-biopterin. The accumulation of 6-biopterin is cytotoxic to normal human melanocytes.https://doi.org/10.1515/pteridines.1995.6.3.101 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Schallreuter-Wood Karin U. Wood John M. |
| spellingShingle |
Schallreuter-Wood Karin U. Wood John M. Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins Pteridines |
| author_facet |
Schallreuter-Wood Karin U. Wood John M. |
| author_sort |
Schallreuter-Wood Karin U. |
| title |
Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins |
| title_short |
Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins |
| title_full |
Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins |
| title_fullStr |
Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins |
| title_full_unstemmed |
Control of Melanogenesis In the Human Epidermis by the Redox-Status of Tetrahydrobiopterins |
| title_sort |
control of melanogenesis in the human epidermis by the redox-status of tetrahydrobiopterins |
| publisher |
De Gruyter |
| series |
Pteridines |
| issn |
0933-4807 2195-4720 |
| publishDate |
1995-08-01 |
| description |
Activity of tyrosinase directly controls melanogenesis in the human epidermis. Recently, it has been shown that the biosynthesis and recycling of (6R)L-erythro 5,6,7,8 tetrahydrobiopterin (6-BH4) plays a central role in regulating the supply of L-tyrosine, the substrate for tyrosinase. In this report, we present evidence that 6-BH4 and other tetrahydropterins, have the capacity to regulate tyrosinase activity directly by a specific uncompetitive mechanism. This fine control of tyrosinase activity/melanogenesis in the human epiidermis depends on the redox equilibrium 6-BH4 ↔ dihydropterin ↔ 6-biopterin. The accumulation of 6-biopterin is cytotoxic to normal human melanocytes. |
| url |
https://doi.org/10.1515/pteridines.1995.6.3.101 |
| work_keys_str_mv |
AT schallreuterwoodkarinu controlofmelanogenesisinthehumanepidermisbytheredoxstatusoftetrahydrobiopterins AT woodjohnm controlofmelanogenesisinthehumanepidermisbytheredoxstatusoftetrahydrobiopterins |
| _version_ |
1717812644801413120 |