Genotype Is Associated to the Degree of Virilization in Patients With Classic Congenital Adrenal Hyperplasia

Genotype Is Associated to the Degree of Virilization in Patients With Classic Congenital Adrenal Hyperplasia

Background: Molecular defects of CYP21A2 consistently decrease 21-hydroxylase activity and result in a variable expression of disease severity in patients with congenital adrenal hyperplasia (CAH).Aim: The genotype and biochemical findings were examined in an attempt to reveal any association to the...

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Bibliographic Details
Main Authors: Vassos Neocleous, Pavlos Fanis, Leonidas A. Phylactou, Nicos Skordis
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Endocrinology
Subjects:
Classic CAH
virilisation
CYP21A2
21-hyrdroxylase deficiency
salt-wasting
Online Access:https://www.frontiersin.org/article/10.3389/fendo.2018.00733/full

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