Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation

Vitamin D and Its Analogues Decrease Amyloid-β (Aβ) Formation and Increase Aβ-Degradation

Alzheimer’s disease (AD) is characterized by extracellular plaques in the brain, mainly consisting of amyloid-β (Aβ), as derived from sequential cleavage of the amyloid precursor protein. Epidemiological studies suggest a tight link between hypovitaminosis of the secosteroid vitamin D and AD. Beside...

Full description

Bibliographic Details
Main Authors:	Marcus O. W. Grimm, Andrea Thiel, Anna A. Lauer, Jakob Winkler, Johannes Lehmann, Liesa Regner, Christopher Nelke, Daniel Janitschke, Céline Benoist, Olga Streidenberger, Hannah Stötzel, Kristina Endres, Christian Herr, Christoph Beisswenger, Heike S. Grimm, Robert Bals, Frank Lammert, Tobias Hartmann
Format:	Article
Language:	English
Published:	MDPI AG 2017-12-01
Series:	International Journal of Molecular Sciences
Subjects:	vitamin D vitamin D analogues amyloid precursor protein amyloid-β secretases Aβ-degradation
Online Access:	https://www.mdpi.com/1422-0067/18/12/2764

Similar Items

Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer’s Disease
by: Marcus O. W. Grimm, et al.
Published: (2016-10-01)

Effect of Caffeine and Other Methylxanthines on Aβ-Homeostasis in SH-SY5Y Cells
by: Daniel Janitschke, et al.
Published: (2019-11-01)

Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
by: Frank Raven, et al.
Published: (2017-10-01)

Neurotoxic effects induced by the Drosophila amyloid-β peptide suggest a conserved toxic function
by: Katia Carmine-Simmen, et al.
Published: (2009-02-01)

BACE1 (β-secretase) knockout mice do not acquire compensatory gene expression changes or develop neural lesions over time
by: Yi Luo, et al.
Published: (2003-10-01)

Making the final cut: pathogenic amyloid-β peptide generation by γ-secretase
by: Harald Steiner, et al.
Published: (2018-10-01)

Caspase inhibition attenuates accumulation of β-amyloid by reducing β-secretase production and activity in rat brains after stroke
by: Man Xiong, et al.
Published: (2008-12-01)

Glycosaminoglycans from <i>Litopenaeus vannamei</i> Inhibit the Alzheimer’s Disease β Secretase, BACE1
by: Courtney J. Mycroft-West, et al.
Published: (2021-04-01)

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase
by: Maho eMorishima-Kawashima
Published: (2014-11-01)

The effect of α-tocopherol, α- and γ-tocotrienols on amyloid-β aggregation and disaggregation in vitro
by: Nor Faeizah Ibrahim, et al.
Published: (2021-12-01)

The Identification of Biochanin A as a Potent and Selective β-Site App-Cleaving Enzyme 1 (Bace1) Inhibitor
by: Kumju Youn, et al.
Published: (2016-10-01)

Residues at P2-P1 positions of ɛ- and ζ-cleavage sites are important in formation of β-amyloid peptide
by: Jianxin Tan, et al.
Published: (2009-12-01)

N-Methyl-d-Aspartate Receptor Antagonist MK-801 and Radical Scavengers Protect Cholinergic Nucleus Basalis Neurons against β-Amyloid Neurotoxicity
by: T. Harkany, et al.
Published: (1999-04-01)

A novel BACE inhibitor isolated from Eisenia bicyclis exhibits neuroprotective activity against β-amyloid toxicity
by: Jung Kwon Lee, et al.
Published: (2018-12-01)

Monoamine oxidase B is elevated in Alzheimer disease neurons, is associated with γ-secretase and regulates neuronal amyloid β-peptide levels
by: Sophia Schedin-Weiss, et al.
Published: (2017-08-01)

Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations
by: Johanna Wanngren, et al.
Published: (2014-01-01)

Sodium phenylbutyrate reverses lysosomal dysfunction and decreases amyloid-β42 in an in vitro-model of inclusion-body myositis
by: Anna Nogalska, et al.
Published: (2014-05-01)

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics
by: Tiwari S, et al.
Published: (2019-07-01)

Mutations in APP have independent effects on Aβ and CTFγ generation
by: Silva Hecimovic, et al.
Published: (2004-11-01)

Discovery of polymethoxyflavones from black ginger (Kaempferia parviflora) as potential β-secretase (BACE1) inhibitors
by: Kumju Youn, et al.
Published: (2016-01-01)

Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production
by: Loukia Parisiadou, et al.
Published: (2008-06-01)

Substrate-Specific Activation of α-Secretase by 7-Deoxy-Trans-Dihydronarciclasine Increases Non-Amyloidogenic Processing of β-Amyloid Protein Precursor
by: Yoon Sun Chun, et al.
Published: (2020-02-01)

Plasma amyloid β 42/40 ratios as biomarkers for amyloid β cerebral deposition in cognitively normal individuals
by: Noelia Fandos, et al.
Published: (2017-01-01)

Effect of β-asarone in normal and β-amyloid-induced Alzheimeric rats
by: Golshid Saki, et al.
Published: (2020-04-01)

Anti-Parallel β-Hairpin Structure in Soluble Aβ Oligomers of Aβ40-Dutch and Aβ40-Iowa
by: Ziao Fu, et al.
Published: (2021-01-01)

Modulation of β-Amyloid Fibril Formation in Alzheimer’s Disease by Microglia and Infection
by: Madeleine R. Brown, et al.
Published: (2020-11-01)

Cathepsin D regulates cerebral Aβ42/40 ratios via differential degradation of Aβ42 and Aβ40
by: Caitlin N. Suire, et al.
Published: (2020-07-01)

Neuroprotective Activity of <i>Mentha</i> Species on Hydrogen Peroxide-Induced Apoptosis in SH-SY5Y Cells
by: Doaa M. Hanafy, et al.
Published: (2020-05-01)

Targeting Amyloidogenic Processing of APP in Alzheimer’s Disease
by: Jing Zhao, et al.
Published: (2020-08-01)

Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice
by: Latha Devi, et al.
Published: (2012-01-01)

Aβ43 in human Alzheimer’s disease: effects of active Aβ42 immunization
by: Lieke Jäkel, et al.
Published: (2019-09-01)

Aβ-40 Y10F Increases βfibrils Formation but Attenuates the Neurotoxicity of Amyloid-β Peptide
by: Zhaofeng Jiang, et al.
Published: (2012-04-01)

Dynamic changes of oligomeric amyloid β levels in plasma induced by spiked synthetic Aβ42
by: Seong Soo A. An, et al.
Published: (2017-10-01)

Presenilin-1 interacts directly with the β-site amyloid protein precursor cleaving enzyme (BACE1)
by: Sébastien S Hébert, et al.
Published: (2003-08-01)

A Glycosaminoglycan Extract from <i>Portunus pelagicus</i> Inhibits BACE1, the β Secretase Implicated in Alzheimer’s Disease
by: Courtney J. Mycroft-West, et al.
Published: (2019-05-01)

Overexpression of Amyloid Precursor Protein Promotes the Onset of Seborrhoeic Keratosis and is Related to Skin Ageing
by: Yuanying Li, et al.
Published: (2018-03-01)

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines
by: Alessio Colombo, et al.
Published: (2013-01-01)

Модуляція активності β-дефензинового захисту в дітей
by: A.E. Abaturov, et al.
Published: (2020-11-01)

Redox-Dependent Copper Ion Modulation of Amyloid-β (1-42) Aggregation In Vitro
by: Nima Sasanian, et al.
Published: (2020-06-01)

β-Amyloid Formation, Memory, and Learning Decline Following Long-term Ovariectomy and Its Inhibition by Systemic Administration of Apigenin and β-Estradiol
by: Seyed Behnamedin Jameie, et al.
Published: (2021-05-01)