Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation

Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation

The microfluidic channel with a planar inductive microcoil for the cell membrane permeabilization and the integrated planar electrodes for cell dielectrophoretic manipulation is proposed and analyzed in the study. The analyzed setup is based on the dielectrophoretic entrapment of the biological cell...

Full description

Bibliographic Details
Main Authors: Novickij V., Grainys A., Novickij J.
Format: Article
Language:English
Published: Sciendo 2013-06-01
Series:Measurement Science Review
Subjects:
pulsed magnetic field
dielectrophoretic entrapment
membrane permeabilization
biological cells
drug delivery
Online Access:https://doi.org/10.2478/msr-2013-0024
id doaj-23c0bcf3e19e4c1493144a8bb8d4ec47
record_format Article
spelling doaj-23c0bcf3e19e4c1493144a8bb8d4ec472021-09-06T19:22:36ZengSciendoMeasurement Science Review1335-88712013-06-0113315215610.2478/msr-2013-0024Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and ManipulationNovickij V.0Grainys A.1Novickij J.2Department of Electrical Engineering, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko street 41, Vilnius LT-03327, LithuaniaDepartment of Electrical Engineering, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko street 41, Vilnius LT-03327, LithuaniaDepartment of Electrical Engineering, Faculty of Electronics, Vilnius Gediminas Technical University, Naugarduko street 41, Vilnius LT-03327, LithuaniaThe microfluidic channel with a planar inductive microcoil for the cell membrane permeabilization and the integrated planar electrodes for cell dielectrophoretic manipulation is proposed and analyzed in the study. The analyzed setup is based on the dielectrophoretic entrapment of the biological cell followed by membrane permeabilization using high pulsed magnetic field. The finite element method analysis of the DEP force and the generated pulsed magnetic field is performed. Based on finite element method analysis the potential applications of the setup in the fields of drug delivery, biomedicine and biotechnology are discussed.https://doi.org/10.2478/msr-2013-0024pulsed magnetic fielddielectrophoretic entrapmentmembrane permeabilizationbiological cellsdrug delivery
collection DOAJ
language English
format Article
sources DOAJ
author Novickij V.
Grainys A.
Novickij J.
spellingShingle Novickij V.
Grainys A.
Novickij J.
Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation
Measurement Science Review
pulsed magnetic field
dielectrophoretic entrapment
membrane permeabilization
biological cells
drug delivery
author_facet Novickij V.
Grainys A.
Novickij J.
author_sort Novickij V.
title Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation
title_short Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation
title_full Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation
title_fullStr Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation
title_full_unstemmed Finite Element Method Analysis of Microfluidic Channel with Integrated Dielectrophoresis Electrodes for Biological Cell Permeabilization and Manipulation
title_sort finite element method analysis of microfluidic channel with integrated dielectrophoresis electrodes for biological cell permeabilization and manipulation
publisher Sciendo
series Measurement Science Review
issn 1335-8871
publishDate 2013-06-01
description The microfluidic channel with a planar inductive microcoil for the cell membrane permeabilization and the integrated planar electrodes for cell dielectrophoretic manipulation is proposed and analyzed in the study. The analyzed setup is based on the dielectrophoretic entrapment of the biological cell followed by membrane permeabilization using high pulsed magnetic field. The finite element method analysis of the DEP force and the generated pulsed magnetic field is performed. Based on finite element method analysis the potential applications of the setup in the fields of drug delivery, biomedicine and biotechnology are discussed.
topic pulsed magnetic field
dielectrophoretic entrapment
membrane permeabilization
biological cells
drug delivery
url https://doi.org/10.2478/msr-2013-0024
work_keys_str_mv AT novickijv finiteelementmethodanalysisofmicrofluidicchannelwithintegrateddielectrophoresiselectrodesforbiologicalcellpermeabilizationandmanipulation
AT grainysa finiteelementmethodanalysisofmicrofluidicchannelwithintegrateddielectrophoresiselectrodesforbiologicalcellpermeabilizationandmanipulation
AT novickijj finiteelementmethodanalysisofmicrofluidicchannelwithintegrateddielectrophoresiselectrodesforbiologicalcellpermeabilizationandmanipulation
_version_ 1717771668759248896

Similar Items