Oxidative Stress and Mitochondrial Activation as the Main Mechanisms Underlying Graphene Toxicity against Human Cancer Cells

Oxidative Stress and Mitochondrial Activation as the Main Mechanisms Underlying Graphene Toxicity against Human Cancer Cells

Due to the development of nanotechnology graphene and graphene-based nanomaterials have attracted the most attention owing to their unique physical, chemical, and mechanical properties. Graphene can be applied in many fields among which biomedical applications especially diagnostics, cancer therapy,...

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Main Authors: Anna Jarosz, Marta Skoda, Ilona Dudek, Dariusz Szukiewicz
Format: Article
Language:English
Published: Hindawi Limited 2016-01-01
Series:Oxidative Medicine and Cellular Longevity
Online Access:http://dx.doi.org/10.1155/2016/5851035
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spelling doaj-23b9ab1efc4144779fbd272e1acc3e1a2020-11-25T01:05:55ZengHindawi LimitedOxidative Medicine and Cellular Longevity1942-09001942-09942016-01-01201610.1155/2016/58510355851035Oxidative Stress and Mitochondrial Activation as the Main Mechanisms Underlying Graphene Toxicity against Human Cancer CellsAnna Jarosz0Marta Skoda1Ilona Dudek2Dariusz Szukiewicz3Department of General & Experimental Pathology and Centre for Preclinical Research and Technology (CEPT), Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, PolandDepartment of General & Experimental Pathology and Centre for Preclinical Research and Technology (CEPT), Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, PolandDepartment of General & Experimental Pathology and Centre for Preclinical Research and Technology (CEPT), Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, PolandDepartment of General & Experimental Pathology and Centre for Preclinical Research and Technology (CEPT), Medical University of Warsaw, Pawińskiego 3C, 02-106 Warsaw, PolandDue to the development of nanotechnology graphene and graphene-based nanomaterials have attracted the most attention owing to their unique physical, chemical, and mechanical properties. Graphene can be applied in many fields among which biomedical applications especially diagnostics, cancer therapy, and drug delivery have been arousing a lot of interest. Therefore it is essential to understand better the graphene-cell interactions, especially toxicity and underlying mechanisms for proper use and development. This review presents the recent knowledge concerning graphene cytotoxicity and influence on different cancer cell lines.http://dx.doi.org/10.1155/2016/5851035
collection DOAJ
language English
format Article
sources DOAJ
author Anna Jarosz
Marta Skoda
Ilona Dudek
Dariusz Szukiewicz
spellingShingle Anna Jarosz
Marta Skoda
Ilona Dudek
Dariusz Szukiewicz
Oxidative Stress and Mitochondrial Activation as the Main Mechanisms Underlying Graphene Toxicity against Human Cancer Cells
Oxidative Medicine and Cellular Longevity
author_facet Anna Jarosz
Marta Skoda
Ilona Dudek
Dariusz Szukiewicz
author_sort Anna Jarosz
title Oxidative Stress and Mitochondrial Activation as the Main Mechanisms Underlying Graphene Toxicity against Human Cancer Cells
title_short Oxidative Stress and Mitochondrial Activation as the Main Mechanisms Underlying Graphene Toxicity against Human Cancer Cells
title_full Oxidative Stress and Mitochondrial Activation as the Main Mechanisms Underlying Graphene Toxicity against Human Cancer Cells
title_fullStr Oxidative Stress and Mitochondrial Activation as the Main Mechanisms Underlying Graphene Toxicity against Human Cancer Cells
title_full_unstemmed Oxidative Stress and Mitochondrial Activation as the Main Mechanisms Underlying Graphene Toxicity against Human Cancer Cells
title_sort oxidative stress and mitochondrial activation as the main mechanisms underlying graphene toxicity against human cancer cells
publisher Hindawi Limited
series Oxidative Medicine and Cellular Longevity
issn 1942-0900
1942-0994
publishDate 2016-01-01
description Due to the development of nanotechnology graphene and graphene-based nanomaterials have attracted the most attention owing to their unique physical, chemical, and mechanical properties. Graphene can be applied in many fields among which biomedical applications especially diagnostics, cancer therapy, and drug delivery have been arousing a lot of interest. Therefore it is essential to understand better the graphene-cell interactions, especially toxicity and underlying mechanisms for proper use and development. This review presents the recent knowledge concerning graphene cytotoxicity and influence on different cancer cell lines.
url http://dx.doi.org/10.1155/2016/5851035
work_keys_str_mv AT annajarosz oxidativestressandmitochondrialactivationasthemainmechanismsunderlyinggraphenetoxicityagainsthumancancercells
AT martaskoda oxidativestressandmitochondrialactivationasthemainmechanismsunderlyinggraphenetoxicityagainsthumancancercells
AT ilonadudek oxidativestressandmitochondrialactivationasthemainmechanismsunderlyinggraphenetoxicityagainsthumancancercells
AT dariuszszukiewicz oxidativestressandmitochondrialactivationasthemainmechanismsunderlyinggraphenetoxicityagainsthumancancercells
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