TGF-β1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse.

TGF-β1 induces an age-dependent inflammation of nerve ganglia and fibroplasia in the prostate gland stroma of a novel transgenic mouse.

TGF-β1 is overexpressed in wound repair and in most proliferative disorders including benign prostatic hyperplasia and prostate cancer. The stromal microenvironment at these sites is reactive and typified by altered phenotype, matrix deposition, inflammatory responses, and alterations in nerve densi...

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Bibliographic Details
Main Authors: David A Barron, Douglas W Strand, Steven J Ressler, Truong D Dang, Simon W Hayward, Feng Yang, Gustavo E Ayala, Michael Ittmann, David R Rowley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-10-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2966419?pdf=render

Internet

http://europepmc.org/articles/PMC2966419?pdf=render

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