Normal fibroblasts induce E-cadherin loss and increase lymph node metastasis in gastric cancer.

Normal fibroblasts induce E-cadherin loss and increase lymph node metastasis in gastric cancer.

BACKGROUND: A tumor is considered a heterogeneous complex in a three-dimensional environment that is flush with pathophysiological and biomechanical signals. Cell-stroma interactions guide the development and generation of tumors. Here, we evaluate the contributions of normal fibroblasts to gastric...

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Bibliographic Details
Main Authors: Wen Xu, Xinlei Hu, Zhongting Chen, Xiaoping Zheng, Chenjing Zhang, Gang Wang, Yu Chen, Xinglu Zhou, Xiaoxiao Tang, Laisheng Luo, Xiang Xu, Wensheng Pan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4028202?pdf=render

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