Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury.

Topiramate treatment is neuroprotective and reduces oligodendrocyte loss after cervical spinal cord injury.

Excess glutamate release and associated neurotoxicity contributes to cell death after spinal cord injury (SCI). Indeed, delayed administration of glutamate receptor antagonists after SCI in rodents improves tissue sparing and functional recovery. Despite their therapeutic potential, most glutamate r...

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Bibliographic Details
Main Authors: John C Gensel, C Amy Tovar, Jacqueline C Bresnahan, Micheal S Beattie
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3302770?pdf=render

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