Evaluation of Marbofloxacin in Beagle Dogs After Oral Dosing: Preclinical Safety Evaluation and Comparative Pharmacokinetics of Two Different Tablets

Evaluation of Marbofloxacin in Beagle Dogs After Oral Dosing: Preclinical Safety Evaluation and Comparative Pharmacokinetics of Two Different Tablets

The current study evaluates a tested marbofloxacin tablet (MBT) (Petsen), in terms of bioavailability and pharmacokinetics (PK) in a comparison of the commercialized and standard tablet (Marbocyl) in beagle dogs. Four different bacterial species were selected for the determination of the minimal inh...

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Bibliographic Details
Main Authors: Zhixin Lei, Qianying Liu, Bing Yang, Haseeb Khaliq, Saeed Ahmed, Bowen Fan, Jiyue Cao, Qigai He
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
fluoroquinolones
marbofloxacin
pharmacokinetics
Beagle dogs
bioavailability
toxicity
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00306/full

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