Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications

Protein Aggregation Landscape in Neurodegenerative Diseases: Clinical Relevance and Future Applications

Intrinsic disorder is a natural feature of polypeptide chains, resulting in the lack of a defined three-dimensional structure. Conformational changes in intrinsically disordered regions of a protein lead to unstable β-sheet enriched intermediates, which are stabilized by intermolecular interactions...

Full description

Bibliographic Details
Main Authors: Niccolò Candelise, Silvia Scaricamazza, Illari Salvatori, Alberto Ferri, Cristiana Valle, Valeria Manganelli, Tina Garofalo, Maurizio Sorice, Roberta Misasi
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
intrinsic disorder
phase separation
protein aggregation
neurodegenerative disease
prion protein
alpha synuclein
Online Access:https://www.mdpi.com/1422-0067/22/11/6016

Internet

https://www.mdpi.com/1422-0067/22/11/6016

Similar Items