Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals

Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals

Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical indu...

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Main Authors: Raúl Benito-Arenas, Sandra G. Zárate, Julia Revuelta, Agatha Bastida
Format: Article
Language:English
Published: MDPI AG 2019-04-01
Series:Catalysts
Subjects:
lyases
chondroitin sulfates
glycosaminoglycan
polysaccharides
Online Access:https://www.mdpi.com/2073-4344/9/4/322
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spelling doaj-23820eb45c2843df824253a36255cd702020-11-25T01:08:20ZengMDPI AGCatalysts2073-43442019-04-019432210.3390/catal9040322catal9040322Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New PharmaceuticalsRaúl Benito-Arenas0Sandra G. Zárate1Julia Revuelta2Agatha Bastida3Departamento de Química Bio-orgánica, IQOG-CSIC. c/Juan de la Cierva 3, E-28006 Madrid, SpainFacultad de Tecnología, Carrera de Ingeniería Química, Universidad Mayor Real y Pontífice de San Francisco Xavier de Chuquisaca, Regimiento Campos 180, Casilla 60-B, Sucre, BoliviaDepartamento de Química Bio-orgánica, IQOG-CSIC. c/Juan de la Cierva 3, E-28006 Madrid, SpainDepartamento de Química Bio-orgánica, IQOG-CSIC. c/Juan de la Cierva 3, E-28006 Madrid, SpainChondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications.https://www.mdpi.com/2073-4344/9/4/322lyaseschondroitin sulfatesglycosaminoglycanpolysaccharides
collection DOAJ
language English
format Article
sources DOAJ
author Raúl Benito-Arenas
Sandra G. Zárate
Julia Revuelta
Agatha Bastida
spellingShingle Raúl Benito-Arenas
Sandra G. Zárate
Julia Revuelta
Agatha Bastida
Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
Catalysts
lyases
chondroitin sulfates
glycosaminoglycan
polysaccharides
author_facet Raúl Benito-Arenas
Sandra G. Zárate
Julia Revuelta
Agatha Bastida
author_sort Raúl Benito-Arenas
title Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title_short Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title_full Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title_fullStr Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title_full_unstemmed Chondroitin Sulfate-Degrading Enzymes as Tools for the Development of New Pharmaceuticals
title_sort chondroitin sulfate-degrading enzymes as tools for the development of new pharmaceuticals
publisher MDPI AG
series Catalysts
issn 2073-4344
publishDate 2019-04-01
description Chondroitin sulfates are linear anionic sulfated polysaccharides found in biological tissues, mainly within the extracellular matrix, which are degraded and altered by specific lyases depending on specific time points. These polysaccharides have recently acquired relevance in the pharmaceutical industry due to their interesting therapeutic applications. As a consequence, chondroitin sulfate (CS) lyases have been widely investigated as tools for the development of new pharmaceuticals based on these polysaccharides. This review focuses on the major breakthrough represented by chondroitin sulfate-degrading enzymes and their structures and mechanisms of function in addition to their major applications.
topic lyases
chondroitin sulfates
glycosaminoglycan
polysaccharides
url https://www.mdpi.com/2073-4344/9/4/322
work_keys_str_mv AT raulbenitoarenas chondroitinsulfatedegradingenzymesastoolsforthedevelopmentofnewpharmaceuticals
AT sandragzarate chondroitinsulfatedegradingenzymesastoolsforthedevelopmentofnewpharmaceuticals
AT juliarevuelta chondroitinsulfatedegradingenzymesastoolsforthedevelopmentofnewpharmaceuticals
AT agathabastida chondroitinsulfatedegradingenzymesastoolsforthedevelopmentofnewpharmaceuticals
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