Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

Low Molecular Weight Fucoidan Inhibits Tumor Angiogenesis through Downregulation of HIF-1/VEGF Signaling under Hypoxia

Activation of hypoxia-induced hypoxia-inducible factors-1 (HIF-1) plays a critical role in promoting tumor angiogenesis, growth and metastasis. Low molecular weight fucoidan (LMWF) is prepared from brown algae, and exhibits anticancer activity. However, whether LMWF attenuates hypoxia-induced angiog...

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Bibliographic Details
Main Authors: Meng-Chuan Chen, Wen-Lin Hsu, Pai-An Hwang, Tz-Chong Chou
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Marine Drugs
Subjects:
low molecular weight fucoidan
angiogenesis
hypoxia-inducible factor 1 alpha
vascular endothelial growth factor
bladder cancer
Online Access:http://www.mdpi.com/1660-3397/13/7/4436

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