A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinomaResearch in context

A PLK1 kinase inhibitor enhances the chemosensitivity of cisplatin by inducing pyroptosis in oesophageal squamous cell carcinomaResearch in context

Background: Targeting PLK1 has recently been proven as a viable therapeutic strategy against oesophageal squamous cell carcinom (ESCC). Therefore, this study aimed to explore whether the PLK1 inhibitor BI2536 is able to sensitize ESCC cells to cisplatin (DDP) and determine the underlying mechanisms....

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Bibliographic Details
Main Authors: Mengjiao Wu, Yan Wang, Di Yang, Ying Gong, Feng Rao, Rui Liu, Yeerken Danna, Jinting Li, Jiawen Fan, Jie Chen, Weimin Zhang, Qimin Zhan
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:EBioMedicine
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396419300842

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http://www.sciencedirect.com/science/article/pii/S2352396419300842

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