Approaches to the Structure-Based Design of Antivirulence Drugs: Therapeutics for the Post-Antibiotic Era

Approaches to the Structure-Based Design of Antivirulence Drugs: Therapeutics for the Post-Antibiotic Era

The alarming rise of multidrug-resistant bacterial strains, coupled with decades of stagnation in the field of antibiotic development, necessitates exploration of new therapeutic approaches to treat bacterial infections. Targeting bacterial virulence is an attractive alternative to traditional antib...

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Main Authors: Nolan Neville, Zongchao Jia
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Molecules
Subjects:
structure-based drug design
crystallography
NMR
modelling
docking
antibiotics
antivirulence drug
Online Access:https://www.mdpi.com/1420-3049/24/3/378
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spelling doaj-2378c9c369714681a428a5c40709d2b32020-11-24T21:34:57ZengMDPI AGMolecules1420-30492019-01-0124337810.3390/molecules24030378molecules24030378Approaches to the Structure-Based Design of Antivirulence Drugs: Therapeutics for the Post-Antibiotic EraNolan Neville0Zongchao Jia1Department of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, CanadaDepartment of Biomedical and Molecular Sciences, Queen’s University, Kingston, ON K7L 3N6, CanadaThe alarming rise of multidrug-resistant bacterial strains, coupled with decades of stagnation in the field of antibiotic development, necessitates exploration of new therapeutic approaches to treat bacterial infections. Targeting bacterial virulence is an attractive alternative to traditional antibiotics in that this approach disarms pathogens that cause human diseases, without placing immediate selective pressure on the target bacterium or harming commensal species. The growing number of validated virulence protein targets for which structural information has been obtained, along with advances in computational power and screening algorithms, make the rational design of antivirulence drugs a promising avenue to explore. Here, we review the principles of structure-based drug design and the exciting opportunities this technique presents for antivirulence drug discovery.https://www.mdpi.com/1420-3049/24/3/378structure-based drug designcrystallographyNMRmodellingdockingantibioticsantivirulence drug
collection DOAJ
language English
format Article
sources DOAJ
author Nolan Neville
Zongchao Jia
spellingShingle Nolan Neville
Zongchao Jia
Approaches to the Structure-Based Design of Antivirulence Drugs: Therapeutics for the Post-Antibiotic Era
Molecules
structure-based drug design
crystallography
NMR
modelling
docking
antibiotics
antivirulence drug
author_facet Nolan Neville
Zongchao Jia
author_sort Nolan Neville
title Approaches to the Structure-Based Design of Antivirulence Drugs: Therapeutics for the Post-Antibiotic Era
title_short Approaches to the Structure-Based Design of Antivirulence Drugs: Therapeutics for the Post-Antibiotic Era
title_full Approaches to the Structure-Based Design of Antivirulence Drugs: Therapeutics for the Post-Antibiotic Era
title_fullStr Approaches to the Structure-Based Design of Antivirulence Drugs: Therapeutics for the Post-Antibiotic Era
title_full_unstemmed Approaches to the Structure-Based Design of Antivirulence Drugs: Therapeutics for the Post-Antibiotic Era
title_sort approaches to the structure-based design of antivirulence drugs: therapeutics for the post-antibiotic era
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2019-01-01
description The alarming rise of multidrug-resistant bacterial strains, coupled with decades of stagnation in the field of antibiotic development, necessitates exploration of new therapeutic approaches to treat bacterial infections. Targeting bacterial virulence is an attractive alternative to traditional antibiotics in that this approach disarms pathogens that cause human diseases, without placing immediate selective pressure on the target bacterium or harming commensal species. The growing number of validated virulence protein targets for which structural information has been obtained, along with advances in computational power and screening algorithms, make the rational design of antivirulence drugs a promising avenue to explore. Here, we review the principles of structure-based drug design and the exciting opportunities this technique presents for antivirulence drug discovery.
topic structure-based drug design
crystallography
NMR
modelling
docking
antibiotics
antivirulence drug
url https://www.mdpi.com/1420-3049/24/3/378
work_keys_str_mv AT nolanneville approachestothestructurebaseddesignofantivirulencedrugstherapeuticsforthepostantibioticera
AT zongchaojia approachestothestructurebaseddesignofantivirulencedrugstherapeuticsforthepostantibioticera
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