ABO blood group differences relationship with coronary atherosclerotic markers

• Main Authors: Hussein Nafakhi, Hasan A. Al-Nafakh, Abdulameer A. Al-Mosawi
• Format: Article
• Language: English
• Published: Atlantis Press 2016-04-01
• Series: Artery Research
• Subjects: ABO blood; Coronary calcification; Pericardial fat; MDCT
• Online Access: https://www.atlantis-press.com/article/125925025/view

Background: The mechanisms linking ABO blood group to coronary atherosclerosis is inconsistent and not fully understood. Objectives: To investigate the relationship between ABO blood groups with coronary atherosclerotic markers (coronary artery calcification (CAC), coronary plaque presence and coronary luminal stenosis (CAD)) and pericardial fat volume (PFV) in patients with suspected coronary artery disease assessed by Multidetector CT angiography (MDCT). Patients and methods: Two hundred twenty consecutive patients who underwent 64-slice MDCT angiography for assessment of coronary artery disease were recruited. Of these, 180 patients (97 females (54%) and 83 males (46%) with a mean age of 51.7 ± 12 years) were found to be eligible and were enrolled in the study. Results: We classified the blood groups into O blood group (51.6%) and non O blood group (38%). There were no significant differences in the distribution of CAC, CAD, PFV and coronary plaque presence between different blood groups (P > 0.05). The distribution of major cardiovascular risk factors did not differ significantly among the ABO blood groups, except for a significant association between O blood group and smoking (P = 0.04). Adjustment for age and sex showed no significant associations between blood groups with coronary atherosclerotic markers or PFV (P > 0.05). Non O blood group were significantly correlated with CAC (P = 0.01), coronary plaque (P = 0.04) and PFV (P = 0.03) after adjustment for CAD and CAC. Conclusion: No significant relationship were observed between ABO blood groups with coronary atherosclerotic markers and PFV. Non O blood group showed a significant correlation with CAC and PFV after adjustment for CAC and CAD.