CD73 expression on effector T cells sustained by TGF-β facilitates tumor resistance to anti-4-1BB/CD137 therapy
Targeting the immune-stimulatory receptor 4-1BB has only yielded modest benefit in cancer treatment. In this study, the authors show that CD73 expression on effector T cells sustained by TGF-β drives tumor resistance to anti-4-1BB therapy and therefore TGF- β blockade can be used to overcome such re...
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Bibliographic Details
| Main Authors: |
Siqi Chen,
Jie Fan,
Minghui Zhang,
Lei Qin,
Donye Dominguez,
Alan Long,
Gaoxiang Wang,
Renqiang Ma,
Huabin Li,
Yi Zhang,
Deyu Fang,
Jeffrey Sosman,
Bin Zhang |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2019-01-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-018-08123-8
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