Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females

Adolescence is a developmental period associated with vast neural and behavioral changes which are accompanied by altered sensitivity to stimuli, both stressful and rewarding. Perturbations, especially stressful stimuli, during this period have been shown to alter behavior in adulthood. Social isola...

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Main Authors: Deena M. Walker, Ashley M. Cunningham, Jill K. Gregory, Eric J. Nestler
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2019.00066/full
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spelling doaj-235fdd024ca544748f4b9733d5c0fffd2020-11-25T02:45:09ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-04-011310.3389/fnbeh.2019.00066440790Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and FemalesDeena M. Walker0Ashley M. Cunningham1Jill K. Gregory2Eric J. Nestler3Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesAcademic IT: Instructional Technology Group, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesAdolescence is a developmental period associated with vast neural and behavioral changes which are accompanied by altered sensitivity to stimuli, both stressful and rewarding. Perturbations, especially stressful stimuli, during this period have been shown to alter behavior in adulthood. Social isolation rearing is one such perturbation. This review highlights the long-term behavioral consequences of adolescent social isolation rearing in rodents with a specific focus on anxiety- and addiction-related behaviors. Sex-specific effects are discussed where data are available. We then consider changes in monoaminergic neurotransmission as one possible mechanism for the behavioral effects described. This research on both normative and perturbed adolescent development is crucial to understanding and treating the increased vulnerability to psychiatric disorders seen in humans during this life stage.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00066/fulladolescenceisolation rearinganxietydepressionrewardaddiction
collection DOAJ
language English
format Article
sources DOAJ
author Deena M. Walker
Ashley M. Cunningham
Jill K. Gregory
Eric J. Nestler
spellingShingle Deena M. Walker
Ashley M. Cunningham
Jill K. Gregory
Eric J. Nestler
Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females
Frontiers in Behavioral Neuroscience
adolescence
isolation rearing
anxiety
depression
reward
addiction
author_facet Deena M. Walker
Ashley M. Cunningham
Jill K. Gregory
Eric J. Nestler
author_sort Deena M. Walker
title Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females
title_short Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females
title_full Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females
title_fullStr Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females
title_full_unstemmed Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females
title_sort long-term behavioral effects of post-weaning social isolation in males and females
publisher Frontiers Media S.A.
series Frontiers in Behavioral Neuroscience
issn 1662-5153
publishDate 2019-04-01
description Adolescence is a developmental period associated with vast neural and behavioral changes which are accompanied by altered sensitivity to stimuli, both stressful and rewarding. Perturbations, especially stressful stimuli, during this period have been shown to alter behavior in adulthood. Social isolation rearing is one such perturbation. This review highlights the long-term behavioral consequences of adolescent social isolation rearing in rodents with a specific focus on anxiety- and addiction-related behaviors. Sex-specific effects are discussed where data are available. We then consider changes in monoaminergic neurotransmission as one possible mechanism for the behavioral effects described. This research on both normative and perturbed adolescent development is crucial to understanding and treating the increased vulnerability to psychiatric disorders seen in humans during this life stage.
topic adolescence
isolation rearing
anxiety
depression
reward
addiction
url https://www.frontiersin.org/article/10.3389/fnbeh.2019.00066/full
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AT ashleymcunningham longtermbehavioraleffectsofpostweaningsocialisolationinmalesandfemales
AT jillkgregory longtermbehavioraleffectsofpostweaningsocialisolationinmalesandfemales
AT ericjnestler longtermbehavioraleffectsofpostweaningsocialisolationinmalesandfemales
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