Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females
Adolescence is a developmental period associated with vast neural and behavioral changes which are accompanied by altered sensitivity to stimuli, both stressful and rewarding. Perturbations, especially stressful stimuli, during this period have been shown to alter behavior in adulthood. Social isola...
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doaj-235fdd024ca544748f4b9733d5c0fffd2020-11-25T02:45:09ZengFrontiers Media S.A.Frontiers in Behavioral Neuroscience1662-51532019-04-011310.3389/fnbeh.2019.00066440790Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and FemalesDeena M. Walker0Ashley M. Cunningham1Jill K. Gregory2Eric J. Nestler3Department of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesAcademic IT: Instructional Technology Group, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesDepartment of Neuroscience and Friedman Brain Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United StatesAdolescence is a developmental period associated with vast neural and behavioral changes which are accompanied by altered sensitivity to stimuli, both stressful and rewarding. Perturbations, especially stressful stimuli, during this period have been shown to alter behavior in adulthood. Social isolation rearing is one such perturbation. This review highlights the long-term behavioral consequences of adolescent social isolation rearing in rodents with a specific focus on anxiety- and addiction-related behaviors. Sex-specific effects are discussed where data are available. We then consider changes in monoaminergic neurotransmission as one possible mechanism for the behavioral effects described. This research on both normative and perturbed adolescent development is crucial to understanding and treating the increased vulnerability to psychiatric disorders seen in humans during this life stage.https://www.frontiersin.org/article/10.3389/fnbeh.2019.00066/fulladolescenceisolation rearinganxietydepressionrewardaddiction |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Deena M. Walker Ashley M. Cunningham Jill K. Gregory Eric J. Nestler |
spellingShingle |
Deena M. Walker Ashley M. Cunningham Jill K. Gregory Eric J. Nestler Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females Frontiers in Behavioral Neuroscience adolescence isolation rearing anxiety depression reward addiction |
author_facet |
Deena M. Walker Ashley M. Cunningham Jill K. Gregory Eric J. Nestler |
author_sort |
Deena M. Walker |
title |
Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females |
title_short |
Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females |
title_full |
Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females |
title_fullStr |
Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females |
title_full_unstemmed |
Long-Term Behavioral Effects of Post-weaning Social Isolation in Males and Females |
title_sort |
long-term behavioral effects of post-weaning social isolation in males and females |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Behavioral Neuroscience |
issn |
1662-5153 |
publishDate |
2019-04-01 |
description |
Adolescence is a developmental period associated with vast neural and behavioral changes which are accompanied by altered sensitivity to stimuli, both stressful and rewarding. Perturbations, especially stressful stimuli, during this period have been shown to alter behavior in adulthood. Social isolation rearing is one such perturbation. This review highlights the long-term behavioral consequences of adolescent social isolation rearing in rodents with a specific focus on anxiety- and addiction-related behaviors. Sex-specific effects are discussed where data are available. We then consider changes in monoaminergic neurotransmission as one possible mechanism for the behavioral effects described. This research on both normative and perturbed adolescent development is crucial to understanding and treating the increased vulnerability to psychiatric disorders seen in humans during this life stage. |
topic |
adolescence isolation rearing anxiety depression reward addiction |
url |
https://www.frontiersin.org/article/10.3389/fnbeh.2019.00066/full |
work_keys_str_mv |
AT deenamwalker longtermbehavioraleffectsofpostweaningsocialisolationinmalesandfemales AT ashleymcunningham longtermbehavioraleffectsofpostweaningsocialisolationinmalesandfemales AT jillkgregory longtermbehavioraleffectsofpostweaningsocialisolationinmalesandfemales AT ericjnestler longtermbehavioraleffectsofpostweaningsocialisolationinmalesandfemales |
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