A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin

A microfluidic approach to rescue ALS motor neuron degeneration using rapamycin

Abstract TAR DNA-binding protein-43 (TDP-43) is known to accumulate in ubiquitinated inclusions of amyotrophic lateral sclerosis affected motor neurons, resulting in motor neuron degeneration, loss of motor functions, and eventually death. Rapamycin, an mTOR inhibitor and a commonly used immunosuppr...

Full description

Bibliographic Details
Main Authors: Phaneendra Chennampally, Ambreen Sayed-Zahid, Prabakaran Soundararajan, Jocelyn Sharp, Gregory A. Cox, Scott D. Collins, Rosemary L. Smith
Format: Article
Language:English
Published: Nature Publishing Group 2021-09-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-97405-1

Similar Items

Similar Items