Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction

Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction

The development of a radiation-induced sarcoma (RIS) in the post mastectomy thoracic treatment volume is an infrequent, but recognized, event. Its frequency is rising in relation with increasing survival of breast cancer patients treated with adjuvant radiation therapy, and is associated with poor p...

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Main Authors: M. Olcina, B. Merck, M. J. Giménez-Climent, S. Almenar, M. F. Sancho-Merle, F. Llopis, C. Vázquez-Albadalejo
Format: Article
Language:English
Published: Hindawi Limited 2008-01-01
Series:Sarcoma
Online Access:http://dx.doi.org/10.1155/2008/456950
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spelling doaj-2349ea406d4f4366871c3dcd5df884e42020-11-24T22:21:02ZengHindawi LimitedSarcoma1357-714X1369-16432008-01-01200810.1155/2008/456950456950Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap ReconstructionM. Olcina0B. Merck1M. J. Giménez-Climent2S. Almenar3M. F. Sancho-Merle4F. Llopis5C. Vázquez-Albadalejo6Surgery Department, Hospital General de Alicante, 03010 Alicante, SpainSurgery Department, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainSurgery Department, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainPathology Department, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainSurgery Department, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainSurgery Department, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainSurgery Department, Fundación Instituto Valenciano de Oncología, 46009 Valencia, SpainThe development of a radiation-induced sarcoma (RIS) in the post mastectomy thoracic treatment volume is an infrequent, but recognized, event. Its frequency is rising in relation with increasing survival of breast cancer patients treated with adjuvant radiation therapy, and is associated with poor prognosis despite treatment. We present a case of leiomyosarcoma in a patient who underwent mastectomy followed by radiotherapy for invasive ductal carcinoma. A delayed TRAM flap reconstruction was performed 10 years after and a rapid growing mass under the reconstructed flap appeared, on routine follow-up, twenty years later. This report analyzes the diagnostic and therapeutic approach of patients with RIS.http://dx.doi.org/10.1155/2008/456950
collection DOAJ
language English
format Article
sources DOAJ
author M. Olcina
B. Merck
M. J. Giménez-Climent
S. Almenar
M. F. Sancho-Merle
F. Llopis
C. Vázquez-Albadalejo
spellingShingle M. Olcina
B. Merck
M. J. Giménez-Climent
S. Almenar
M. F. Sancho-Merle
F. Llopis
C. Vázquez-Albadalejo
Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction
Sarcoma
author_facet M. Olcina
B. Merck
M. J. Giménez-Climent
S. Almenar
M. F. Sancho-Merle
F. Llopis
C. Vázquez-Albadalejo
author_sort M. Olcina
title Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction
title_short Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction
title_full Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction
title_fullStr Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction
title_full_unstemmed Radiation-Induced Leiomyosarcoma after Breast Cancer Treatment and TRAM Flap Reconstruction
title_sort radiation-induced leiomyosarcoma after breast cancer treatment and tram flap reconstruction
publisher Hindawi Limited
series Sarcoma
issn 1357-714X
1369-1643
publishDate 2008-01-01
description The development of a radiation-induced sarcoma (RIS) in the post mastectomy thoracic treatment volume is an infrequent, but recognized, event. Its frequency is rising in relation with increasing survival of breast cancer patients treated with adjuvant radiation therapy, and is associated with poor prognosis despite treatment. We present a case of leiomyosarcoma in a patient who underwent mastectomy followed by radiotherapy for invasive ductal carcinoma. A delayed TRAM flap reconstruction was performed 10 years after and a rapid growing mass under the reconstructed flap appeared, on routine follow-up, twenty years later. This report analyzes the diagnostic and therapeutic approach of patients with RIS.
url http://dx.doi.org/10.1155/2008/456950
work_keys_str_mv AT molcina radiationinducedleiomyosarcomaafterbreastcancertreatmentandtramflapreconstruction
AT bmerck radiationinducedleiomyosarcomaafterbreastcancertreatmentandtramflapreconstruction
AT mjgimenezcliment radiationinducedleiomyosarcomaafterbreastcancertreatmentandtramflapreconstruction
AT salmenar radiationinducedleiomyosarcomaafterbreastcancertreatmentandtramflapreconstruction
AT mfsanchomerle radiationinducedleiomyosarcomaafterbreastcancertreatmentandtramflapreconstruction
AT fllopis radiationinducedleiomyosarcomaafterbreastcancertreatmentandtramflapreconstruction
AT cvazquezalbadalejo radiationinducedleiomyosarcomaafterbreastcancertreatmentandtramflapreconstruction
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