Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53

Metformin Restores Parkin-Mediated Mitophagy, Suppressed by Cytosolic p53

Metformin is known to alleviate hepatosteatosis by inducing 5’ adenosine monophosphate (AMP)-kinase-independent, sirtuin 1 (SIRT1)-mediated autophagy. Dysfunctional mitophagy in response to glucolipotoxicities might play an important role in hepatosteatosis. Here, we investigated the mechanism by wh...

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Bibliographic Details
Main Authors: Young Mi Song, Woo Kyung Lee, Yong-ho Lee, Eun Seok Kang, Bong-Soo Cha, Byung-Wan Lee
Format: Article
Language:English
Published: MDPI AG 2016-01-01
Series:International Journal of Molecular Sciences
Subjects:
mitophagy
p53
Parkin
mitochondrial spheroid
metformin
Online Access:http://www.mdpi.com/1422-0067/17/1/122

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