β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in <i>Caenorhabditis elegans</i> Model

β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in <i>Caenorhabditis elegans</i> Model

&#946;-Cryptoxanthin (BCX) is a major dietary pro-vitamin A carotenoid, found mainly in fruits and vegetables. Several studies showed the beneficial effects of BCX on different aspects of human health. In spite of the evidence, the molecular mechanisms of action of BCX need to be further investi...

Full description

Bibliographic Details
Main Authors: Silvia Llopis, María Jesús Rodrigo, Nuria González, Salvador Genovés, Lorenzo Zacarías, Daniel Ramón, Patricia Martorell
Format: Article
Language:English
Published: MDPI AG 2019-01-01
Series:Nutrients
Subjects:
β-Cryptoxanthin
carotenoids
<i>Caenorhabditis elegans</i>
fat reduction
oxidative stress
transcriptomic analysis
metabolic syndrome
aging
Online Access:https://www.mdpi.com/2072-6643/11/2/232
id doaj-23491d29ab3a45ac878bf1e8f41174e0
record_format Article
spelling doaj-23491d29ab3a45ac878bf1e8f41174e02020-11-24T21:16:59ZengMDPI AGNutrients2072-66432019-01-0111223210.3390/nu11020232nu11020232β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in <i>Caenorhabditis elegans</i> ModelSilvia Llopis0María Jesús Rodrigo1Nuria González2Salvador Genovés3Lorenzo Zacarías4Daniel Ramón5Patricia Martorell6Cell Biology Laboratory, Food Biotechnology Department, Biópolis SL/Archer Daniels Midland, C/Catedrático Agustín Escardino Benlloch 9, Paterna, 46890 Valencia, SpainFood Biotechnology Department, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), C/Catedrático Agustín Escardino 7, Paterna, 46890 Valencia, SpainCell Biology Laboratory, Food Biotechnology Department, Biópolis SL/Archer Daniels Midland, C/Catedrático Agustín Escardino Benlloch 9, Paterna, 46890 Valencia, SpainCell Biology Laboratory, Food Biotechnology Department, Biópolis SL/Archer Daniels Midland, C/Catedrático Agustín Escardino Benlloch 9, Paterna, 46890 Valencia, SpainFood Biotechnology Department, Instituto de Agroquímica y Tecnología de Alimentos (IATA), Consejo Superior de Investigaciones Científicas (CSIC), C/Catedrático Agustín Escardino 7, Paterna, 46890 Valencia, SpainCell Biology Laboratory, Food Biotechnology Department, Biópolis SL/Archer Daniels Midland, C/Catedrático Agustín Escardino Benlloch 9, Paterna, 46890 Valencia, SpainCell Biology Laboratory, Food Biotechnology Department, Biópolis SL/Archer Daniels Midland, C/Catedrático Agustín Escardino Benlloch 9, Paterna, 46890 Valencia, Spain&#946;-Cryptoxanthin (BCX) is a major dietary pro-vitamin A carotenoid, found mainly in fruits and vegetables. Several studies showed the beneficial effects of BCX on different aspects of human health. In spite of the evidence, the molecular mechanisms of action of BCX need to be further investigated. The <i>Caenorhabditis elegans</i> model was used to analyze in vivo the activity of BCX on fat reduction and protection to oxidative stress. Dose-response assays provided evidence of the efficacy of BCX at very low dose (0.025 &#181;g/mL) (<i>p</i> &lt; 0.001) on these processes. Moreover, a comparative analysis with other carotenoids, such as lycopene and &#946;-carotene, showed a stronger effect of BCX. Furthermore, a transcriptomic analysis of wild-type nematodes supplemented with BCX revealed upregulation of the energy metabolism, response to stress, and protein homeostasis as the main metabolic targets of this xanthophyll. Collectively, this study provides new in vivo evidence of the potential therapeutic use of BCX in the prevention of diseases related to metabolic syndrome and aging.https://www.mdpi.com/2072-6643/11/2/232β-Cryptoxanthincarotenoids<i>Caenorhabditis elegans</i>fat reductionoxidative stresstranscriptomic analysismetabolic syndromeaging
collection DOAJ
language English
format Article
sources DOAJ
author Silvia Llopis
María Jesús Rodrigo
Nuria González
Salvador Genovés
Lorenzo Zacarías
Daniel Ramón
Patricia Martorell
spellingShingle Silvia Llopis
María Jesús Rodrigo
Nuria González
Salvador Genovés
Lorenzo Zacarías
Daniel Ramón
Patricia Martorell
β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in <i>Caenorhabditis elegans</i> Model
Nutrients
β-Cryptoxanthin
carotenoids
<i>Caenorhabditis elegans</i>
fat reduction
oxidative stress
transcriptomic analysis
metabolic syndrome
aging
author_facet Silvia Llopis
María Jesús Rodrigo
Nuria González
Salvador Genovés
Lorenzo Zacarías
Daniel Ramón
Patricia Martorell
author_sort Silvia Llopis
title β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in <i>Caenorhabditis elegans</i> Model
title_short β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in <i>Caenorhabditis elegans</i> Model
title_full β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in <i>Caenorhabditis elegans</i> Model
title_fullStr β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in <i>Caenorhabditis elegans</i> Model
title_full_unstemmed β-Cryptoxanthin Reduces Body Fat and Increases Oxidative Stress Response in <i>Caenorhabditis elegans</i> Model
title_sort β-cryptoxanthin reduces body fat and increases oxidative stress response in <i>caenorhabditis elegans</i> model
publisher MDPI AG
series Nutrients
issn 2072-6643
publishDate 2019-01-01
description &#946;-Cryptoxanthin (BCX) is a major dietary pro-vitamin A carotenoid, found mainly in fruits and vegetables. Several studies showed the beneficial effects of BCX on different aspects of human health. In spite of the evidence, the molecular mechanisms of action of BCX need to be further investigated. The <i>Caenorhabditis elegans</i> model was used to analyze in vivo the activity of BCX on fat reduction and protection to oxidative stress. Dose-response assays provided evidence of the efficacy of BCX at very low dose (0.025 &#181;g/mL) (<i>p</i> &lt; 0.001) on these processes. Moreover, a comparative analysis with other carotenoids, such as lycopene and &#946;-carotene, showed a stronger effect of BCX. Furthermore, a transcriptomic analysis of wild-type nematodes supplemented with BCX revealed upregulation of the energy metabolism, response to stress, and protein homeostasis as the main metabolic targets of this xanthophyll. Collectively, this study provides new in vivo evidence of the potential therapeutic use of BCX in the prevention of diseases related to metabolic syndrome and aging.
topic β-Cryptoxanthin
carotenoids
<i>Caenorhabditis elegans</i>
fat reduction
oxidative stress
transcriptomic analysis
metabolic syndrome
aging
url https://www.mdpi.com/2072-6643/11/2/232
work_keys_str_mv AT silviallopis bcryptoxanthinreducesbodyfatandincreasesoxidativestressresponseinicaenorhabditiselegansimodel
AT mariajesusrodrigo bcryptoxanthinreducesbodyfatandincreasesoxidativestressresponseinicaenorhabditiselegansimodel
AT nuriagonzalez bcryptoxanthinreducesbodyfatandincreasesoxidativestressresponseinicaenorhabditiselegansimodel
AT salvadorgenoves bcryptoxanthinreducesbodyfatandincreasesoxidativestressresponseinicaenorhabditiselegansimodel
AT lorenzozacarias bcryptoxanthinreducesbodyfatandincreasesoxidativestressresponseinicaenorhabditiselegansimodel
AT danielramon bcryptoxanthinreducesbodyfatandincreasesoxidativestressresponseinicaenorhabditiselegansimodel
AT patriciamartorell bcryptoxanthinreducesbodyfatandincreasesoxidativestressresponseinicaenorhabditiselegansimodel
_version_ 1726014943392694272

Similar Items