Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysi...

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Main Authors:	Maria Contaldo, Mariarosaria Boccellino, Giuseppa Zannini, Antonio Romano, Antonella Sciarra, Alessandra Sacco, Giuliana Settembre, Mario Coppola, Angelina Di Carlo, Luigi D’Angelo, Francesco Inchingolo, Antonia Feola, Marina Di Domenico
Format:	Article
Language:	English
Published:	Hindawi Limited 2020-01-01
Series:	Journal of Oncology
Online Access:	http://dx.doi.org/10.1155/2020/9587971

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spelling	doaj-233b3e0b47144ada85bfe5c202b6b1c52020-11-25T03:07:24ZengHindawi LimitedJournal of Oncology1687-84501687-84692020-01-01202010.1155/2020/95879719587971Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of ViewMaria Contaldo0Mariarosaria Boccellino1Giuseppa Zannini2Antonio Romano3Antonella Sciarra4Alessandra Sacco5Giuliana Settembre6Mario Coppola7Angelina Di Carlo8Luigi D’Angelo9Francesco Inchingolo10Antonia Feola11Marina Di Domenico12Multidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, Naples, NA, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, NA, ItalyDepartment of Biology, University of Naples “Federico II”, Naples, NA, ItalyMultidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, Naples, NA, ItalyDepartment of Experimental Medicine, University of Campania “Luigi Vanvitelli”, Naples, NA, ItalyCell Biology and Biotherapy Unit, Tumor National Istitute “Fondazione G. Pascale”-IRCCS, Naples, NA, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, NA, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, NA, ItalyDepartment of Medico-Surgical Sciences and Biotechnologies, “Sapienza” University of Rome, Rome, ItalyMultidisciplinary Department of Medical, Surgical and Dental Specialties, University of Campania “Luigi Vanvitelli”, Naples, NA, ItalyDepartment of Interdisciplinary Medicine, School of Medicine, University of Bari Aldo Moro, Bari, ItalyDepartment of Biology, University of Naples “Federico II”, Naples, NA, ItalyDepartment of Precision Medicine, University of Campania “Luigi Vanvitelli”, Naples, NA, ItalyOral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases introduce a vicious circle of nonhealing and perpetuation of the inflammatory processes, thus leading toward cancer occurrence via local and systemic inflammatory modulators and via genetic and epigenetic factors.http://dx.doi.org/10.1155/2020/9587971
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maria Contaldo Mariarosaria Boccellino Giuseppa Zannini Antonio Romano Antonella Sciarra Alessandra Sacco Giuliana Settembre Mario Coppola Angelina Di Carlo Luigi D’Angelo Francesco Inchingolo Antonia Feola Marina Di Domenico
spellingShingle	Maria Contaldo Mariarosaria Boccellino Giuseppa Zannini Antonio Romano Antonella Sciarra Alessandra Sacco Giuliana Settembre Mario Coppola Angelina Di Carlo Luigi D’Angelo Francesco Inchingolo Antonia Feola Marina Di Domenico Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View Journal of Oncology
author_facet	Maria Contaldo Mariarosaria Boccellino Giuseppa Zannini Antonio Romano Antonella Sciarra Alessandra Sacco Giuliana Settembre Mario Coppola Angelina Di Carlo Luigi D’Angelo Francesco Inchingolo Antonia Feola Marina Di Domenico
author_sort	Maria Contaldo
title	Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View
title_short	Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View
title_full	Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View
title_fullStr	Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View
title_full_unstemmed	Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View
title_sort	sex hormones and inflammation role in oral cancer progression: a molecular and biological point of view
publisher	Hindawi Limited
series	Journal of Oncology
issn	1687-8450 1687-8469
publishDate	2020-01-01
description	Oral cancers have been proven to arise from precursors lesions and to be related to risk behaviour such as alcohol consumption and smoke. However, the present paper focuses on the role of chronic inflammation, related to chronical oral infections and/or altered immune responses occurring during dysimmune and autoimmune diseases, in the oral cancerogenesis. Particularly, oral candidiasis and periodontal diseases introduce a vicious circle of nonhealing and perpetuation of the inflammatory processes, thus leading toward cancer occurrence via local and systemic inflammatory modulators and via genetic and epigenetic factors.
url	http://dx.doi.org/10.1155/2020/9587971
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Sex Hormones and Inflammation Role in Oral Cancer Progression: A Molecular and Biological Point of View

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