Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy

Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy while dramatically increasing REM sleep, indicatin...

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Main Authors: Ali Seifinejad, Sha Li, Marie-Laure Possovre, Anne Vassalli, Mehdi Tafti
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19862-y
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spelling doaj-2338f9f632924b529de47dc3761ffb852021-05-11T08:41:58ZengNature Publishing GroupNature Communications2041-17232020-11-0111111210.1038/s41467-020-19862-yHypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexyAli Seifinejad0Sha Li1Marie-Laure Possovre2Anne Vassalli3Mehdi Tafti4Department of Biomedical Sciences, Faculty of Biology and Medicine, University of LausanneDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of LausanneDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of LausanneDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of LausanneDepartment of Biomedical Sciences, Faculty of Biology and Medicine, University of LausanneNarcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy while dramatically increasing REM sleep, indicating that these are two different states but are both regulated by hypocretinergic input to serotonergic neurons.https://doi.org/10.1038/s41467-020-19862-y
collection DOAJ
language English
format Article
sources DOAJ
author Ali Seifinejad
Sha Li
Marie-Laure Possovre
Anne Vassalli
Mehdi Tafti
spellingShingle Ali Seifinejad
Sha Li
Marie-Laure Possovre
Anne Vassalli
Mehdi Tafti
Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
Nature Communications
author_facet Ali Seifinejad
Sha Li
Marie-Laure Possovre
Anne Vassalli
Mehdi Tafti
author_sort Ali Seifinejad
title Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_short Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_full Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_fullStr Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_full_unstemmed Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
title_sort hypocretinergic interactions with the serotonergic system regulate rem sleep and cataplexy
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Narcolepsy is characterized by a sudden loss of muscle tone (cataplexy) similar to REM sleep and is caused by hypocretin deficiency. Here, the authors show that deleting the serotonin transporter gene in hypocretin knockout mice suppresses cataplexy while dramatically increasing REM sleep, indicating that these are two different states but are both regulated by hypocretinergic input to serotonergic neurons.
url https://doi.org/10.1038/s41467-020-19862-y
work_keys_str_mv AT aliseifinejad hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy
AT shali hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy
AT marielaurepossovre hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy
AT annevassalli hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy
AT mehditafti hypocretinergicinteractionswiththeserotonergicsystemregulateremsleepandcataplexy
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