Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer.

Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer.

BACKGROUND:MLL3 is a histone 3-lysine 4 methyltransferase with tumor-suppressor properties that belongs to a family of chromatin regulator genes potentially altered in neoplasia. Mutations in MLL3 were found in a whole genome analysis of colorectal cancer but have not been confirmed by a separate st...

Full description

Bibliographic Details
Main Authors: Yoshiyuki Watanabe, Ryan J Castoro, Hyun Soo Kim, Brittany North, Ritsuko Oikawa, Tetsuya Hiraishi, Saira S Ahmed, Woonbok Chung, Mee-Yon Cho, Minoru Toyota, Fumio Itoh, Marcos R H Estecio, Lanlan Shen, Jaroslav Jelinek, Jean-Pierre J Issa
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3154922?pdf=render

Internet

http://europepmc.org/articles/PMC3154922?pdf=render

Similar Items