Potential Applications of NRF2 Modulators in Cancer Therapy

Potential Applications of NRF2 Modulators in Cancer Therapy

The nuclear factor erythroid 2-related factor 2 (NRF2)−Kelch-like ECH-associated protein 1 (KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from oxidative, electrophilic, and xenobiotic stress. By controlling the transactivation of over 500 cytoprotective...

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Bibliographic Details
Main Authors: Emiliano Panieri, Aleksandra Buha, Pelin Telkoparan-Akillilar, Dilek Cevik, Demetrios Kouretas, Aristidis Veskoukis, Zoi Skaperda, Aristidis Tsatsakis, David Wallace, Sibel Suzen, Luciano Saso
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Antioxidants
Subjects:
nrf2-keap1
ros
cancer metabolism
antioxidant
oxidative stress
cancer therapy
chemoresistance
radioresistance
Online Access:https://www.mdpi.com/2076-3921/9/3/193

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