Improvement of a predictive model of castration-resistant prostate cancer: functional genetic variants in TGFβ1 signaling pathway modulation.

Improvement of a predictive model of castration-resistant prostate cancer: functional genetic variants in TGFβ1 signaling pathway modulation.

Prostate cancer (PC) is the most frequently diagnosed cancer in men. The acquisition of castration-resistant (CR) phenotype is associated with the activation of signaling pathways mediated by growth factors. The TGFβ1 and its receptors have an important role in tumor progression, being the pro-apopt...

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Bibliographic Details
Main Authors: Ana L Teixeira, Mónica Gomes, Augusto Nogueira, Andreia S Azevedo, Joana Assis, Francisca Dias, Juliana I Santos, Francisco Lobo, António Morais, Joaquina Maurício, Rui Medeiros
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23951322/pdf/?tool=EBI

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