Function and Interactions of ERCC1-XPF in DNA Damage Response

Function and Interactions of ERCC1-XPF in DNA Damage Response

Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particula...

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Bibliographic Details
Main Authors: Maryam Faridounnia, Gert E. Folkers, Rolf Boelens
Format: Article
Language:English
Published: MDPI AG 2018-12-01
Series:Molecules
Subjects:
ERCC1
XPF
DSB repair
ICL repair
NER
DNA damage response
Fanconi anemia
Online Access:https://www.mdpi.com/1420-3049/23/12/3205
Description
Summary:Numerous proteins are involved in the multiple pathways of the DNA damage response network and play a key role to protect the genome from the wide variety of damages that can occur to DNA. An example of this is the structure-specific endonuclease ERCC1-XPF. This heterodimeric complex is in particular involved in nucleotide excision repair (NER), but also in double strand break repair and interstrand cross-link repair pathways. Here we review the function of ERCC1-XPF in various DNA repair pathways and discuss human disorders associated with ERCC1-XPF deficiency. We also overview our molecular and structural understanding of XPF-ERCC1.
ISSN:1420-3049

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