Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells

Oligonucleotides blocking glucosylceramide synthase expression selectively reverse drug resistance in cancer cells

High glucosylceramide synthase (GCS) activity is one factor contributing to multidrug resistance (MDR) in breast cancer. Enforced GCS overexpression has been shown to disrupt ceramide-induced apoptosis and to confer resistance to doxorubicin. To examine whether GCS is a target for cancer therapy, we...

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Bibliographic Details
Main Authors: Yong-Yu Liu, Tie Yan Han, Jing Yuan Yu, Arie Bitterman, Ahn Le, Armando E. Giuliano, Myles C. Cabot
Format: Article
Language:English
Published: Elsevier 2004-05-01
Series:Journal of Lipid Research
Subjects:
ceramide
antisense oligonucleotides
apoptosis
chemotherapy
breast cancer
doxorubicin
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520318344

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