Patient Derived Colonoids as Drug Testing Platforms–Critical Importance of Oxygen Concentration

Patient Derived Colonoids as Drug Testing Platforms–Critical Importance of Oxygen Concentration

Treatment of inflammatory bowel disease (IBD) is challenging, with a series of available drugs each helping only a fraction of patients. Patients may face time-consuming drug trials while the disease is active, thus there is an unmet need for biomarkers and assays to predict drug effect. It is well...

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Bibliographic Details
Main Authors: Helene Kolstad Skovdahl, Shreya Gopalakrishnan, Tarjei Dahl Svendsen, Atle van Beelen Granlund, Ingunn Bakke, Zekarias G. Ginbot, Silje Thorsvik, Arnar Flatberg, Bjørnar Sporsheim, Jenny Ostrop, Tom Eirik Mollnes, Arne Kristian Sandvik, Torunn Bruland
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Pharmacology
Subjects:
inflammatory bowel diseases
epithelium
organoids
oxygen
cytokines
tumor necrosis factor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.679741/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.679741/full

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