High salt loading induces urinary storage dysfunction via upregulation of epithelial sodium channel alpha in the bladder epithelium in Dahl salt-sensitive rats

High salt loading induces urinary storage dysfunction via upregulation of epithelial sodium channel alpha in the bladder epithelium in Dahl salt-sensitive rats

We aimed to investigate whether high salt intake affects bladder function via epithelial sodium channel (ENaC) by using Dahl salt-resistant (DR) and salt-sensitive (DS) rats. Bladder weight of DR + high-salt diet (HS, 8% NaCl) and DS + HS groups were significantly higher than those of DR + normal-sa...

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Bibliographic Details
Main Authors: Seiji Yamamoto, Yuji Hotta, Kotomi Maeda, Tomoya Kataoka, Yasuhiro Maeda, Takashi Hamakawa, Yasuhiro Shibata, Shoichi Sasaki, Shinya Ugawa, Takahiro Yasui, Kazunori Kimura
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Journal of Pharmacological Sciences
Subjects:
Animal experimentation
Dietary sodium chloride
Epithelial sodium channel
Salt-sensitive hypertension
Storage symptom
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861317301706

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