Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-κB Pathway

Inhibiting DNA Methylation Improves Survival in Severe Sepsis by Regulating NF-κB Pathway

Organ dysfunction caused by sepsis is life-threatening and results in high mortality. Therapeutic options for sepsis are limited. Pathogenic factors are considered as components of environmental pressure that modify DNA methylation patterns thereby enhancing disease progression. Here, we found that...

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Bibliographic Details
Main Authors: Luxi Cao, Tingting Zhu, Xiabing Lang, Sha Jia, Yi Yang, Chaohong Zhu, Yucheng Wang, Shi Feng, Cuili Wang, Ping Zhang, Jianghua Chen, Hong Jiang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Immunology
Subjects:
DNA methylation
sepsis
CLP
NF-κB pathway
DNMTs
inflammatory cytokine
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.01360/full

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