Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks
Although resting-state functional connectivity is a commonly used neuroimaging paradigm, the underlying mechanisms remain unknown. Thalamo-cortical and cortico-cortical circuits generate oscillations at different frequencies during spontaneous activity. However, it remains unclear how the various rh...
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doaj-22ef67ec31cc4039a9c8c08f42a7ae552020-11-24T23:37:29ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2015-12-01910.3389/fnins.2015.00454153731Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinksRoberto C Sotero0Alekasandra Beata Bortel1Shmuel eNaaman2Victor Mihai Mocanu3Pascal eKropf4Martin eVilleneuve5Amir eShmuel6McGill UniversityMcGill UniversityMcGill UniversityMcGill UniversityMcGill UniversityMcGill UniversityMcGill UniversityAlthough resting-state functional connectivity is a commonly used neuroimaging paradigm, the underlying mechanisms remain unknown. Thalamo-cortical and cortico-cortical circuits generate oscillations at different frequencies during spontaneous activity. However, it remains unclear how the various rhythms interact and whether their interactions are lamina-specific. Here we investigated intra- and inter-laminar spontaneous phase-amplitude coupling (PAC). We recorded local-field potentials using laminar probes inserted in the forelimb representation of rat area S1. We then computed time-series of frequency-band- and lamina-specific current source density (CSD), and PACs of CSD for all possible pairs of the classical frequency bands in the range of 1–150 Hz. We observed both intra- and inter-laminar spontaneous PAC. Of 18 possible combinations, 12 showed PAC, with the highest measures of interaction obtained for the pairs of the theta/gamma and delta/gamma bands. Intra- and inter-laminar PACs involving layers 2/3–5a were higher than those involving layer 6. Current sinks (sources) in the delta band were associated with increased (decreased) amplitudes of high-frequency signals in the beta to fast gamma bands throughout layers 2/3–6. Spontaneous sinks (sources) of the theta and alpha bands in layers 2/3 to 4 were on average linked to dipoles completed by sources (sinks) in layer 6, associated with high (low) amplitudes of the beta to fast-gamma bands in the entire cortical column. Our findings show that during spontaneous activity, delta, theta, and alpha oscillations are associated with periodic excitability, which for the theta and alpha bands is lamina--dependent. They further emphasize the differences between the function of layer 6 and that of the superficial layers, and the role of layer 6 in controlling activity in those layers. Our study links theories on the involvement of PAC in resting-state functional connectivity with previous work that revealed lamina-specific anatomical thalamo-cortico-cortical connections.http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00454/fullfunctional connectivityresting statespontaneous activityLFPCross-frequency couplingCSD |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Roberto C Sotero Alekasandra Beata Bortel Shmuel eNaaman Victor Mihai Mocanu Pascal eKropf Martin eVilleneuve Amir eShmuel |
spellingShingle |
Roberto C Sotero Alekasandra Beata Bortel Shmuel eNaaman Victor Mihai Mocanu Pascal eKropf Martin eVilleneuve Amir eShmuel Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks Frontiers in Neuroscience functional connectivity resting state spontaneous activity LFP Cross-frequency coupling CSD |
author_facet |
Roberto C Sotero Alekasandra Beata Bortel Shmuel eNaaman Victor Mihai Mocanu Pascal eKropf Martin eVilleneuve Amir eShmuel |
author_sort |
Roberto C Sotero |
title |
Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks |
title_short |
Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks |
title_full |
Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks |
title_fullStr |
Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks |
title_full_unstemmed |
Laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks |
title_sort |
laminar distribution of phase-amplitude coupling of spontaneous current sources and sinks |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Neuroscience |
issn |
1662-453X |
publishDate |
2015-12-01 |
description |
Although resting-state functional connectivity is a commonly used neuroimaging paradigm, the underlying mechanisms remain unknown. Thalamo-cortical and cortico-cortical circuits generate oscillations at different frequencies during spontaneous activity. However, it remains unclear how the various rhythms interact and whether their interactions are lamina-specific. Here we investigated intra- and inter-laminar spontaneous phase-amplitude coupling (PAC). We recorded local-field potentials using laminar probes inserted in the forelimb representation of rat area S1. We then computed time-series of frequency-band- and lamina-specific current source density (CSD), and PACs of CSD for all possible pairs of the classical frequency bands in the range of 1–150 Hz. We observed both intra- and inter-laminar spontaneous PAC. Of 18 possible combinations, 12 showed PAC, with the highest measures of interaction obtained for the pairs of the theta/gamma and delta/gamma bands. Intra- and inter-laminar PACs involving layers 2/3–5a were higher than those involving layer 6. Current sinks (sources) in the delta band were associated with increased (decreased) amplitudes of high-frequency signals in the beta to fast gamma bands throughout layers 2/3–6. Spontaneous sinks (sources) of the theta and alpha bands in layers 2/3 to 4 were on average linked to dipoles completed by sources (sinks) in layer 6, associated with high (low) amplitudes of the beta to fast-gamma bands in the entire cortical column. Our findings show that during spontaneous activity, delta, theta, and alpha oscillations are associated with periodic excitability, which for the theta and alpha bands is lamina--dependent. They further emphasize the differences between the function of layer 6 and that of the superficial layers, and the role of layer 6 in controlling activity in those layers. Our study links theories on the involvement of PAC in resting-state functional connectivity with previous work that revealed lamina-specific anatomical thalamo-cortico-cortical connections. |
topic |
functional connectivity resting state spontaneous activity LFP Cross-frequency coupling CSD |
url |
http://journal.frontiersin.org/Journal/10.3389/fnins.2015.00454/full |
work_keys_str_mv |
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