Molecular mechanisms of tiling and self-avoidance in neural development
<p>Abstract</p> <p>Recent studies have begun to unravel the molecular basis of tiling and self-avoidance, two important cellular mechanisms that shape neuronal circuitry during development in both invertebrates and vertebrates. Dscams and Turtle (Tutl), two Ig superfamily proteins,...
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BMC
2010-10-01
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| Series: | Molecular Brain |
| Online Access: | http://www.molecularbrain.com/content/3/1/28 |
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doaj-22edecd8ee324cbc9129d368a1901cc42020-11-24T22:17:23ZengBMCMolecular Brain1756-66062010-10-01312810.1186/1756-6606-3-28Molecular mechanisms of tiling and self-avoidance in neural developmentCameron ScottRao Yong<p>Abstract</p> <p>Recent studies have begun to unravel the molecular basis of tiling and self-avoidance, two important cellular mechanisms that shape neuronal circuitry during development in both invertebrates and vertebrates. Dscams and Turtle (Tutl), two Ig superfamily proteins, have been shown to mediate contact-dependent homotypic interactions in tiling and self-avoidance. By contrast, the Activin pathway regulates axonal tiling in a contact-independent manner. These cell surface signals may directly or indirectly regulate the activity of the Tricornered kinase pathway and/or other intracellular signaling pathways to prevent the overlap between same-type neuronal arbors in the sensory or synaptic input field.</p> http://www.molecularbrain.com/content/3/1/28 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Cameron Scott Rao Yong |
| spellingShingle |
Cameron Scott Rao Yong Molecular mechanisms of tiling and self-avoidance in neural development Molecular Brain |
| author_facet |
Cameron Scott Rao Yong |
| author_sort |
Cameron Scott |
| title |
Molecular mechanisms of tiling and self-avoidance in neural development |
| title_short |
Molecular mechanisms of tiling and self-avoidance in neural development |
| title_full |
Molecular mechanisms of tiling and self-avoidance in neural development |
| title_fullStr |
Molecular mechanisms of tiling and self-avoidance in neural development |
| title_full_unstemmed |
Molecular mechanisms of tiling and self-avoidance in neural development |
| title_sort |
molecular mechanisms of tiling and self-avoidance in neural development |
| publisher |
BMC |
| series |
Molecular Brain |
| issn |
1756-6606 |
| publishDate |
2010-10-01 |
| description |
<p>Abstract</p> <p>Recent studies have begun to unravel the molecular basis of tiling and self-avoidance, two important cellular mechanisms that shape neuronal circuitry during development in both invertebrates and vertebrates. Dscams and Turtle (Tutl), two Ig superfamily proteins, have been shown to mediate contact-dependent homotypic interactions in tiling and self-avoidance. By contrast, the Activin pathway regulates axonal tiling in a contact-independent manner. These cell surface signals may directly or indirectly regulate the activity of the Tricornered kinase pathway and/or other intracellular signaling pathways to prevent the overlap between same-type neuronal arbors in the sensory or synaptic input field.</p> |
| url |
http://www.molecularbrain.com/content/3/1/28 |
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