Effect of lanosterol on human cataract nucleus

• Main Authors: P Mahesh Shanmugam, Aditya Barigali, Jayant Kadaskar, Sandip Borgohain, Divaynsh Kailash Chandra Mishra, Rajesh Ramanjulu, C K Minija
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2015-01-01
• Series: Indian Journal of Ophthalmology
• Subjects: Cataract; human; lanosterol; reversal
• Online Access: http://www.ijo.in/article.asp?issn=0301-4738;year=2015;volume=63;issue=12;spage=888;epage=890;aulast=Shanmugam
• ISSN: 0301-4738; 1998-3689

Aim: To study the effect of lanosterol on age-related cataractous human lens nuclei. Materials and Methods: Forty age-related cataractous nuclei removed during manual small incision cataract surgery were obtained and randomly immersed in 25 mM lanosterol solution or in control solution and stored at room temperature for 6 days. Pre- and post-immersion photographs were graded by two masked observers and collated for the regression or progression of lens opacity. Results: Both lanosterol and control groups showed progression or no change in the lens opacity at the end of 6 days. Conclusion: Lanosterol 25 mM solution did not reverse opacification of human age-related cataractous nuclei.