The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs

The role of sex, age and genetic polymorphisms of CYP enzymes on the pharmacokinetics of anticholinergic drugs

Abstract There is evidence that use of drugs with anticholinergic properties increases the risk of cognitive impairment, and increased exposure to these drugs potentiates this risk. Anticholinergic drugs are commonly used even with associated risk of adverse events. Aging, sex, and genetic polymorph...

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Bibliographic Details
Main Authors: Shanna C. Trenaman, Susan K. Bowles, Melissa K. Andrew, Kerry Goralski
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Pharmacology Research & Perspectives
Subjects:
aging
anticholinergics
pharmacokinetics
sex differences
Online Access:https://doi.org/10.1002/prp2.775

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