Stability-indicating spectrofluorimetric method with enhanced sensitivity for determination of vancomycin hydrochloride in pharmaceuticals and spiked human plasma: Application to degradation kinetics

Stability-indicating spectrofluorimetric method with enhanced sensitivity for determination of vancomycin hydrochloride in pharmaceuticals and spiked human plasma: Application to degradation kinetics

Based on investigating the relative fluorescence intensity of vancomycin hydrochloride (VCM) in methanol, a simple, highly sensitive, time-saving and specific spectrofluorimetric method was developed and validated. VCM fluorescence was measured at 335 nm when excited at 268 nm. Excellent linearity i...

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Bibliographic Details
Main Authors: Mohie Khaled Sharaf El-Din, Fawzia Ibrahim, Asmaa Kamal El-Deen, Kuniyoshi Shimizu
Format: Article
Language:English
Published: Elsevier 2018-04-01
Series:Journal of Food and Drug Analysis
Online Access:http://www.sciencedirect.com/science/article/pii/S1021949817301321

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