Acute effect of phosphodiesterase type 5 inhibitor on serum oxidative status and prolidase activities in men with erectile dysfunction

• Main Authors: Murat Savas, Ercan Yeni, Ayhan Verit, Mehmet Gulum, Nurten Aksoy, Halil Ciftci, Hakim Celik, Adem Altunkol, Halil Oncel
• Format: Article
• Language: English
• Published: Faculdade de Medicina / USP 2010-01-01
• Series: Clinics
• Subjects: Phosphodiesterase type 5 inhibitors; Tadalafil citrate; Total antioxidant status; Total oxidant status; Prolidase
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1807-59322010001200014

OBJECTIVES: To investigate the acute effect of phosphodiesterase type 5 (PDE5) inhibitor on erectile dysfunction by evaluating serum oxidative status and prolidase activity. METHODS: Serum samples of 36 patients with erectile dysfunction and 30 control cases were analyzed for total antioxidant status, total oxidant status, and prolidase activity, before and after the administration of tadalafil citrate. RESULTS: Before and after tadalafil citrate administration, serum total antioxidant status, total oxidant status, and prolidase were 1.1+0.0 vs. 1.6 + 0.0 umol H2O2 Eq/L, 10.3+1.1 vs. 6.9 + 1.2 umol H2O2 Eq/L, and 236.4+19.5 vs. 228.2 + 19.2 U/L, respectively (p<0.0001 for all). CONCLUSIONS: Evaluation of serum oxidative status and prolidase activity confirmed the beneficial acute effects of PDE5 inhibitor in patients with erectile dysfunction.