Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?

Background. Renewed interest in vinegar as a glucose-lowering agent led to several small trials in the recent past. However, none of the trials could independently provide sufficient evidence. Objectives. Our review aimed to obtain reliable estimates of effects of vinegar on short-term and long-term...

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Main Authors: Fahad Javaid Siddiqui MSc, Pryseley Nkouibert Assam PhD, Nurun Nisa de Souza MPH, Rehena Sultana MSc, Rinkoo Dalan FRCP, Edwin Shih-Yen Chan PhD
Format: Article
Language:English
Published: SAGE Publishing 2018-05-01
Series:Journal of Evidence-Based Integrative Medicine
Online Access:https://doi.org/10.1177/2156587217753004
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spelling doaj-22c1e58b16c44e918865c515258f30bd2020-11-25T02:54:29ZengSAGE PublishingJournal of Evidence-Based Integrative Medicine2515-690X2018-05-012310.1177/2156587217753004Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?Fahad Javaid Siddiqui MSc0Pryseley Nkouibert Assam PhD1Nurun Nisa de Souza MPH2Rehena Sultana MSc3Rinkoo Dalan FRCP4Edwin Shih-Yen Chan PhD5 Duke-NUS Graduate Medical School, Singapore, Singapore Singapore Clinical Research Institute, Singapore, Singapore Singapore Clinical Research Institute, Singapore, Singapore Duke-NUS Graduate Medical School, Singapore, Singapore Tan Tock Seng Hospital, Singapore, Singapore Cochrane Singapore, SingaporeBackground. Renewed interest in vinegar as a glucose-lowering agent led to several small trials in the recent past. However, none of the trials could independently provide sufficient evidence. Objectives. Our review aimed to obtain reliable estimates of effects of vinegar on short-term and long-term blood glucose control. Methods. Large bibliographic databases were searched from inception to date of search without language and publication date restrictions. All clinical trials evaluating effect of vinegar on diabetes mellitus patients were eligible. Two authors independently extracted data on fasting and 2-hour postprandial blood glucose, insulin, and HbA1c levels at the various time points. MS Excel, SAS® v9.3, and RevMan v5.3 were used for data analysis. Results. Small significant reduction in mean HbA1c was observed after 8 to 12 weeks of vinegar administration: −0.39% (95% confidence interval = −0.59, −0.18; I 2 = 0%). Other long-term outcomes favored vinegar but were not significant. Short-term outcomes showed significantly lower pooled mean difference in glucose levels at 30 minutes in the vinegar group. Readings at 60, 90, and 120 minutes were lower in the vinegar group but not statistically significant. Adverse effects profile also favored the vinegar group. Conclusions. It is worthwhile to carry out carefully planned large trails to determine the efficacy and effectiveness of vinegar as an adjunct treatment modality.https://doi.org/10.1177/2156587217753004
collection DOAJ
language English
format Article
sources DOAJ
author Fahad Javaid Siddiqui MSc
Pryseley Nkouibert Assam PhD
Nurun Nisa de Souza MPH
Rehena Sultana MSc
Rinkoo Dalan FRCP
Edwin Shih-Yen Chan PhD
spellingShingle Fahad Javaid Siddiqui MSc
Pryseley Nkouibert Assam PhD
Nurun Nisa de Souza MPH
Rehena Sultana MSc
Rinkoo Dalan FRCP
Edwin Shih-Yen Chan PhD
Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?
Journal of Evidence-Based Integrative Medicine
author_facet Fahad Javaid Siddiqui MSc
Pryseley Nkouibert Assam PhD
Nurun Nisa de Souza MPH
Rehena Sultana MSc
Rinkoo Dalan FRCP
Edwin Shih-Yen Chan PhD
author_sort Fahad Javaid Siddiqui MSc
title Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?
title_short Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?
title_full Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?
title_fullStr Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?
title_full_unstemmed Diabetes Control: Is Vinegar a Promising Candidate to Help Achieve Targets?
title_sort diabetes control: is vinegar a promising candidate to help achieve targets?
publisher SAGE Publishing
series Journal of Evidence-Based Integrative Medicine
issn 2515-690X
publishDate 2018-05-01
description Background. Renewed interest in vinegar as a glucose-lowering agent led to several small trials in the recent past. However, none of the trials could independently provide sufficient evidence. Objectives. Our review aimed to obtain reliable estimates of effects of vinegar on short-term and long-term blood glucose control. Methods. Large bibliographic databases were searched from inception to date of search without language and publication date restrictions. All clinical trials evaluating effect of vinegar on diabetes mellitus patients were eligible. Two authors independently extracted data on fasting and 2-hour postprandial blood glucose, insulin, and HbA1c levels at the various time points. MS Excel, SAS® v9.3, and RevMan v5.3 were used for data analysis. Results. Small significant reduction in mean HbA1c was observed after 8 to 12 weeks of vinegar administration: −0.39% (95% confidence interval = −0.59, −0.18; I 2 = 0%). Other long-term outcomes favored vinegar but were not significant. Short-term outcomes showed significantly lower pooled mean difference in glucose levels at 30 minutes in the vinegar group. Readings at 60, 90, and 120 minutes were lower in the vinegar group but not statistically significant. Adverse effects profile also favored the vinegar group. Conclusions. It is worthwhile to carry out carefully planned large trails to determine the efficacy and effectiveness of vinegar as an adjunct treatment modality.
url https://doi.org/10.1177/2156587217753004
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