Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

Roles of TET and TDG in DNA demethylation in proliferating and non-proliferating immune cells

Abstract Background TET enzymes mediate DNA demethylation by oxidizing 5-methylcytosine (5mC) in DNA to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC). Since these oxidized methylcytosines (oxi-mCs) are not recognized by the maintenance methyltransferase DNMT1,...

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Bibliographic Details
Main Authors:	Atsushi Onodera, Edahí González-Avalos, Chan-Wang Jerry Lio, Romain O. Georges, Alfonso Bellacosa, Toshinori Nakayama, Anjana Rao
Format:	Article
Language:	English
Published:	BMC 2021-06-01
Series:	Genome Biology
Online Access:	https://doi.org/10.1186/s13059-021-02384-1

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