Molecular architecture and regulation of BCL10-MALT1 filaments

Molecular architecture and regulation of BCL10-MALT1 filaments

The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.

Bibliographic Details
Main Authors: Florian Schlauderer, Thomas Seeholzer, Ambroise Desfosses, Torben Gehring, Mike Strauss, Karl-Peter Hopfner, Irina Gutsche, Daniel Krappmann, Katja Lammens
Format: Article
Language:English
Published: Nature Publishing Group 2018-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-06573-8
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spelling doaj-22b52c92e3104c5888ae0b4dd5745f982021-05-11T10:34:09ZengNature Publishing GroupNature Communications2041-17232018-10-019111210.1038/s41467-018-06573-8Molecular architecture and regulation of BCL10-MALT1 filamentsFlorian Schlauderer0Thomas Seeholzer1Ambroise Desfosses2Torben Gehring3Mike Strauss4Karl-Peter Hopfner5Irina Gutsche6Daniel Krappmann7Katja Lammens8Gene Center, Ludwig-Maximilians UniversityResearch Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz-Zentrum München - German Research Center for Environmental HealthUniversity Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale IBSResearch Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz-Zentrum München - German Research Center for Environmental HealthDepartment of Anatomy and Cell Biology, McGill UniversityGene Center, Ludwig-Maximilians UniversityUniversity Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale IBSResearch Unit Cellular Signal Integration, Institute of Molecular Toxicology and Pharmacology, Helmholtz-Zentrum München - German Research Center for Environmental HealthGene Center, Ludwig-Maximilians UniversityThe BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.https://doi.org/10.1038/s41467-018-06573-8
collection DOAJ
language English
format Article
sources DOAJ
author Florian Schlauderer
Thomas Seeholzer
Ambroise Desfosses
Torben Gehring
Mike Strauss
Karl-Peter Hopfner
Irina Gutsche
Daniel Krappmann
Katja Lammens
spellingShingle Florian Schlauderer
Thomas Seeholzer
Ambroise Desfosses
Torben Gehring
Mike Strauss
Karl-Peter Hopfner
Irina Gutsche
Daniel Krappmann
Katja Lammens
Molecular architecture and regulation of BCL10-MALT1 filaments
Nature Communications
author_facet Florian Schlauderer
Thomas Seeholzer
Ambroise Desfosses
Torben Gehring
Mike Strauss
Karl-Peter Hopfner
Irina Gutsche
Daniel Krappmann
Katja Lammens
author_sort Florian Schlauderer
title Molecular architecture and regulation of BCL10-MALT1 filaments
title_short Molecular architecture and regulation of BCL10-MALT1 filaments
title_full Molecular architecture and regulation of BCL10-MALT1 filaments
title_fullStr Molecular architecture and regulation of BCL10-MALT1 filaments
title_full_unstemmed Molecular architecture and regulation of BCL10-MALT1 filaments
title_sort molecular architecture and regulation of bcl10-malt1 filaments
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-10-01
description The BCL10-MALT1 complex is a central signaling hub in lymphocytes and linked to various human immune pathologies. Here the authors present the cryo-EM structure of the BCL10-MALT1 filament core and verify the identified BCL10/MALT1 interface with mutagenesis studies.
url https://doi.org/10.1038/s41467-018-06573-8
work_keys_str_mv AT florianschlauderer moleculararchitectureandregulationofbcl10malt1filaments
AT thomasseeholzer moleculararchitectureandregulationofbcl10malt1filaments
AT ambroisedesfosses moleculararchitectureandregulationofbcl10malt1filaments
AT torbengehring moleculararchitectureandregulationofbcl10malt1filaments
AT mikestrauss moleculararchitectureandregulationofbcl10malt1filaments
AT karlpeterhopfner moleculararchitectureandregulationofbcl10malt1filaments
AT irinagutsche moleculararchitectureandregulationofbcl10malt1filaments
AT danielkrappmann moleculararchitectureandregulationofbcl10malt1filaments
AT katjalammens moleculararchitectureandregulationofbcl10malt1filaments
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