Metabolic engineering of Escherichia coli BL21 (DE3) for de novo production of l-DOPA from d-glucose

Metabolic engineering of Escherichia coli BL21 (DE3) for de novo production of l-DOPA from d-glucose

Abstract Background Production of l-tyrosine is gaining grounds as the market size of 3,4-dihydroxyphenyl-l-alanine (l-DOPA) is expected to increase due to increasing cases of Parkinson’s disease a neurodegenerative disease. Attempts to overproduce l-tyrosine for conversion to l-DOPA has stemmed on...

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Bibliographic Details
Main Authors: Eric Fordjour, Frederick Komla Adipah, Shenghu Zhou, Guocheng Du, Jingwen Zhou
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Microbial Cell Factories
Subjects:
l-Tyrosine
4-Hydroxyphenylacetate 3-monooxygenase
Melanization
Modular expression
Parkinson’s disease
Online Access:http://link.springer.com/article/10.1186/s12934-019-1122-0

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http://link.springer.com/article/10.1186/s12934-019-1122-0

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