The origin of heterogeneous nanoparticle uptake by cells

Cellular uptake of nanoparticles is highly variable between individual cells in a population. Here, the authors show that this heterogeneity is a result of varying numbers of nanoparticle-containing endosomes while the nanoparticle dose per endosome remains constant.

Bibliographic Details
Main Authors: Paul Rees, John W. Wills, M. Rowan Brown, Claire M. Barnes, Huw D. Summers
Format: Article
Language:English
Published: Nature Publishing Group 2019-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-10112-4
Description
Summary:Cellular uptake of nanoparticles is highly variable between individual cells in a population. Here, the authors show that this heterogeneity is a result of varying numbers of nanoparticle-containing endosomes while the nanoparticle dose per endosome remains constant.
ISSN:2041-1723