LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation

The Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a hyper-activated kinase, causing loss of homeostasis...

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Main Authors:	Prabhjot Kaur, Marvin Rausch, Basanti Malakar, Uchenna Watson, Nikhil P. Damle, Yogesh Chawla, Sandhya Srinivasan, Kanika Sharma, Tanja Schneider, Gagan Deep Jhingan, Deepak Saini, Debasisa Mohanty, Fabian Grein, Vinay Kumar Nandicoori
Format:	Article
Language:	English
Published:	Nature Publishing Group 2019-03-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-019-09223-9

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spelling	doaj-229dcd6f9fca48209698162286590a152021-05-11T12:18:25ZengNature Publishing GroupNature Communications2041-17232019-03-0110111710.1038/s41467-019-09223-9LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activationPrabhjot Kaur0Marvin Rausch1Basanti Malakar2Uchenna Watson3Nikhil P. Damle4Yogesh Chawla5Sandhya Srinivasan6Kanika Sharma7Tanja Schneider8Gagan Deep Jhingan9Deepak Saini10Debasisa Mohanty11Fabian Grein12Vinay Kumar Nandicoori13National Institute of ImmunologyInstitute for Pharmaceutical Microbiology, University Hospital Bonn, University of BonnNational Institute of ImmunologyDepartment of Molecular Reproduction, Development and Genetics, Indian Institute of ScienceNational Institute of ImmunologyNational Institute of ImmunologyVproteomics, Valerian Chem Private LimitedVproteomics, Valerian Chem Private LimitedInstitute for Pharmaceutical Microbiology, University Hospital Bonn, University of BonnVproteomics, Valerian Chem Private LimitedDepartment of Molecular Reproduction, Development and Genetics, Indian Institute of ScienceNational Institute of ImmunologyInstitute for Pharmaceutical Microbiology, University Hospital Bonn, University of BonnNational Institute of ImmunologyThe Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a hyper-activated kinase, causing loss of homeostasis and cell death.https://doi.org/10.1038/s41467-019-09223-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Prabhjot Kaur Marvin Rausch Basanti Malakar Uchenna Watson Nikhil P. Damle Yogesh Chawla Sandhya Srinivasan Kanika Sharma Tanja Schneider Gagan Deep Jhingan Deepak Saini Debasisa Mohanty Fabian Grein Vinay Kumar Nandicoori
spellingShingle	Prabhjot Kaur Marvin Rausch Basanti Malakar Uchenna Watson Nikhil P. Damle Yogesh Chawla Sandhya Srinivasan Kanika Sharma Tanja Schneider Gagan Deep Jhingan Deepak Saini Debasisa Mohanty Fabian Grein Vinay Kumar Nandicoori LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation Nature Communications
author_facet	Prabhjot Kaur Marvin Rausch Basanti Malakar Uchenna Watson Nikhil P. Damle Yogesh Chawla Sandhya Srinivasan Kanika Sharma Tanja Schneider Gagan Deep Jhingan Deepak Saini Debasisa Mohanty Fabian Grein Vinay Kumar Nandicoori
author_sort	Prabhjot Kaur
title	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_short	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_full	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_fullStr	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_full_unstemmed	LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation
title_sort	lipidii interaction with specific residues of mycobacterium tuberculosis pknb extracytoplasmic domain governs its optimal activation
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2019-03-01
description	The Mycobacterium tuberculosis kinase PknB regulates essential cell functions via interactions with muropeptides. Here the authors identify interaction sites in the extracytoplasmic PASTA domain and show that abrogation of ligand binding leads to a hyper-activated kinase, causing loss of homeostasis and cell death.
url	https://doi.org/10.1038/s41467-019-09223-9
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LipidII interaction with specific residues of Mycobacterium tuberculosis PknB extracytoplasmic domain governs its optimal activation

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