Efficiency of use of autologous activated serum in coxarthrosis

• Main Authors: S M Noskov, L Iu Shirokova, A V Snigireva, O M Parulia, S D Dybin
• Format: Article
• Language: Russian
• Published: "Consilium Medicum" Publishing house 2012-08-01
• Series: Терапевтический архив
• Subjects: coxarthrosis; local therapy; hyalyronic acid; autologous conditioned serum
• Online Access: https://ter-arkhiv.ru/0040-3660/article/view/31068
• ISSN: 0040-3660; 2309-5342

Aim. To evaluate the clinical efficiency of using autologous conditioned (activated) serum (ACS) versus hyaluronic acid (HA) in coxarthrosis (CA). Subjects and methods. Two groups of patients (n=54) who were matched for age, sex, and disease duration and had a valid diagnosis of CA were examined. During 3 weeks, Groups 1 and 2 patients received intra-articular therapy with ACS or synocrome forte (Croma Pharma, Sоtex), respectively, for 3 weeks. A 12-month follow-up evaluated the magnitude of pain, by using the visual analog scale (VAS, mm), the functional index WOMAC and general health, by applying the EQ-VAS scale. Results. The only benefit of HA was found to be more functional improvement as detected by the WOMAC index (-21.8%; t=2.56) at an early (1-month) follow-up. After 3 months, the patients in the ACS group were recorded to have the maximum VAS pain intensity reduction that was 76.5% greater than that (t=4.31) in the HA group. The clearest advantages of ACS therapy were traced 6 months after treatment. Conclusion. The use of ACS may be a real alternative to that of HA derivatives in achieving good clinical outcomes in patients with CA. After ACS administration, there was a long-term preservation of achieved positive results.