Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria
The C2 sulfonates taurine and isethionate are also present in the anaerobic mammalian gut, where they are converted into toxic H2S by sulfate and sulfite-reducing bacteria. Here the authors characterise the O2-sensitive enzyme IseG that catalyzes the C-S bond cleavage of isethionate and show that Is...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2019-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-019-09618-8 |
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doaj-2282a632ed40415c96252d41aafc4d49 |
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Article |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Meining Xing Yifeng Wei Yan Zhou Jun Zhang Lianyun Lin Yiling Hu Gaoqun Hua Ankanahalli N. Nanjaraj Urs Dazhi Liu Feifei Wang Cuixia Guo Yang Tong Mengya Li Yanhong Liu Ee Lui Ang Huimin Zhao Zhiguang Yuchi Yan Zhang |
| spellingShingle |
Meining Xing Yifeng Wei Yan Zhou Jun Zhang Lianyun Lin Yiling Hu Gaoqun Hua Ankanahalli N. Nanjaraj Urs Dazhi Liu Feifei Wang Cuixia Guo Yang Tong Mengya Li Yanhong Liu Ee Lui Ang Huimin Zhao Zhiguang Yuchi Yan Zhang Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria Nature Communications |
| author_facet |
Meining Xing Yifeng Wei Yan Zhou Jun Zhang Lianyun Lin Yiling Hu Gaoqun Hua Ankanahalli N. Nanjaraj Urs Dazhi Liu Feifei Wang Cuixia Guo Yang Tong Mengya Li Yanhong Liu Ee Lui Ang Huimin Zhao Zhiguang Yuchi Yan Zhang |
| author_sort |
Meining Xing |
| title |
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria |
| title_short |
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria |
| title_full |
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria |
| title_fullStr |
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria |
| title_full_unstemmed |
Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteria |
| title_sort |
radical-mediated c-s bond cleavage in c2 sulfonate degradation by anaerobic bacteria |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2019-04-01 |
| description |
The C2 sulfonates taurine and isethionate are also present in the anaerobic mammalian gut, where they are converted into toxic H2S by sulfate and sulfite-reducing bacteria. Here the authors characterise the O2-sensitive enzyme IseG that catalyzes the C-S bond cleavage of isethionate and show that IseG also plays a key role in converting taurine into H2S in Bilophila wadsworthia. |
| url |
https://doi.org/10.1038/s41467-019-09618-8 |
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doaj-2282a632ed40415c96252d41aafc4d492021-05-11T12:21:16ZengNature Publishing GroupNature Communications2041-17232019-04-0110111110.1038/s41467-019-09618-8Radical-mediated C-S bond cleavage in C2 sulfonate degradation by anaerobic bacteriaMeining Xing0Yifeng Wei1Yan Zhou2Jun Zhang3Lianyun Lin4Yiling Hu5Gaoqun Hua6Ankanahalli N. Nanjaraj Urs7Dazhi Liu8Feifei Wang9Cuixia Guo10Yang Tong11Mengya Li12Yanhong Liu13Ee Lui Ang14Huimin Zhao15Zhiguang Yuchi16Yan Zhang17Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityMetabolic Engineering Research Laboratory, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTechnical Institute of Physics and Chemistry, Chinese Academy of SciencesMetabolic Engineering Research Laboratory, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)Metabolic Engineering Research Laboratory, Institute of Chemical and Engineering Sciences, Agency for Science, Technology and Research (A*STAR)Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityTianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin UniversityThe C2 sulfonates taurine and isethionate are also present in the anaerobic mammalian gut, where they are converted into toxic H2S by sulfate and sulfite-reducing bacteria. Here the authors characterise the O2-sensitive enzyme IseG that catalyzes the C-S bond cleavage of isethionate and show that IseG also plays a key role in converting taurine into H2S in Bilophila wadsworthia.https://doi.org/10.1038/s41467-019-09618-8 |